{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:55:59Z","timestamp":1791575759245,"version":"4.3.4"},"reference-count":59,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 24\u2010year\u2010old man with non\u2010lesional bitemporal lobe epilepsy since age 16\u2009years was found dead in bed around midday. He was last seen the previous night when he was witnessed to have a tonic\u2013clonic seizure. Before his death, he was experiencing weekly focal impaired awareness seizures and up to two focal\u2010to\u2010bilateral tonic\u2013clonic seizures each year. He had trialed several antiseizure medications and was on levetiracetam 1500\u2009mg\/day, lamotrigine 400\u2009mg\/day, and clobazam 10\u2009mg\/day at the time of death. Other than epilepsy, his medical history was unremarkable. Of note, he had an older brother with a history of febrile seizures and a paternal first cousin with epilepsy. No cause of death was identified following a comprehensive postmortem investigation. The coroner classified the death as \u201csudden unexpected death in epilepsy\u201d (SUDEP), and it would qualify as \u201cdefinite SUDEP\u201d using the current definitions.<jats:sup>1<\/jats:sup> This left the family with many questions unanswered; in particular, they wish to know what caused the death and whether it could happen to other family members. Could postmortem genetic testing identify a cause of death, provide closure to the family, and facilitate cascade genetic testing of first\u2010degree family members who may be at risk of sudden death? While grieving family members struggle with uncertainty about the cause of death, we as clinicians also face similar uncertainties about genetic contributions to SUDEP, especially when the literature is sparse, and the utility of genetic testing is still being worked out. We aim to shed some light on this topic, highlighting areas where data is emerging but also areas where uncertainty remains, keeping our case in mind as we examine this clinically important area.<\/jats:p>","DOI":"10.1002\/epd2.20090","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T09:04:52Z","timestamp":1687338292000},"page":"472-479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["ILAE Genetic Literacy Series: Postmortem Genetic Testing in Sudden Unexpected Death in Epilepsy"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2476-9864","authenticated-orcid":false,"given":"Richard D.","family":"Bagnall","sequence":"first","affiliation":[{"name":"Agnes Ginges Centre for Molecular Cardiology at Centenary Institute University of Sydney  Sydney New\u00a0South Wales Australia"},{"name":"Faculty of Medicine and Health University of Sydney  Sydney New\u00a0South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7855-7066","authenticated-orcid":false,"given":"Piero","family":"Perucca","sequence":"additional","affiliation":[{"name":"Department of Medicine (Austin Health), Epilepsy Research Centre The University of Melbourne  Melbourne Victoria Australia"},{"name":"Bladin\u2010Berkovic Comprehensive Epilepsy Program, Department of Neurology Austin Health  Melbourne Victoria Australia"},{"name":"Department of Neuroscience, Central Clinical School Monash University  Melbourne Victoria Australia"},{"name":"Department of Neurology Alfred Health  Melbourne Victoria Australia"},{"name":"Department of Neurology The Royal Melbourne Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the ILAE Genetics 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