{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T01:55:28Z","timestamp":1780365328403,"version":"3.54.1"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":46,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Musicogenic epilepsy (ME), a peculiar form of reflex epilepsy, represents a neurological rarity and yet another demonstration of the extraordinary power of music on the human brain. Despite the heterogeneity of the reported musical triggers, patients' emotional response to music is thought to play a crucial role in provoking seizures. Accordingly, the mesial temporal structures (especially of the non\u2010dominant hemisphere) appear most involved in seizure generation, although a more complex fronto\u2010temporal epileptogenic network was documented in some cases. Autoimmune encephalitis has been recently included among the many possible aetiologies of ME based on a few reports of music\u2010induced seizures in patients with anti\u2010glutamic acid decarboxylase 65 antibodies. Here, we describe the case of a 25\u2010year\u2010old man, educated in music over a long period of time, who had suffered from drug\u2010resistant temporal lobe epilepsy following seronegative limbic encephalitis related to non\u2010Hodgkin lymphoma. Along with spontaneous events, the patient also developed musicogenic seizures later in the disease course. After detecting five music\u2010induced episodes via 24\u2010hour ambulatory EEG, we performed prolonged video\u2010EEG monitoring during which the patient presented a right temporal seizure (characterized by <jats:italic>d\u00e9j\u00e0\u2010vu<\/jats:italic>, piloerection and gustatory hallucinations) while listening to a hard rock song through headphones (which he had not previously heard). This observation allowed us to confirm the provoking effect of the music on our patient's seizures, despite the lack of any emotional drive, which suggests that a \u201ccognitive\u201d trigger was more likely in this case. Our report further highlights that autoimmune encephalitis should be investigated as a novel potential cause of musicogenic epilepsy, regardless of autoantibody status.<\/jats:p>","DOI":"10.1684\/epd.2021.1322","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T07:05:30Z","timestamp":1635231930000},"page":"754-759","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Musicogenic epilepsy in paraneoplastic limbic encephalitis: a video\u2010EEG case report"],"prefix":"10.1002","volume":"23","author":[{"given":"Alessandra","family":"Morano","sequence":"first","affiliation":[{"name":"Epilepsy Centre, Department of Human Neurosciences \u201cSapienza\u201d University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biagio","family":"Orlando","sequence":"additional","affiliation":[{"name":"Epilepsy Centre, Department of Human Neurosciences \u201cSapienza\u201d University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Fanella","sequence":"additional","affiliation":[{"name":"Epilepsy Centre, Department of Human Neurosciences \u201cSapienza\u201d University of Rome Rome Italy"},{"name":"Neurology Unit Ospedale \u201cSan Camillo de' Lellis\u201d Rieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele Cerulli","family":"Irelli","sequence":"additional","affiliation":[{"name":"Epilepsy Centre, Department of Human Neurosciences \u201cSapienza\u201d University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Colonnese","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit IRCCS \u201cNeuromed\u201d Pozzilli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierpaolo","family":"Quarato","sequence":"additional","affiliation":[{"name":"Epilepsy Surgery Unit IRCSS \u201cNeuromed\u201d Pozzilli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Teresa","family":"Giallonardo","sequence":"additional","affiliation":[{"name":"Epilepsy Centre, Department of Human Neurosciences \u201cSapienza\u201d University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Di Bonaventura","sequence":"additional","affiliation":[{"name":"Epilepsy Centre, Department of Human Neurosciences \u201cSapienza\u201d University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,16]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"273","volume-title":"Reflex epilepsies and reflex seizures. Advances in Neurology","author":"Zifkin B.G.","year":"1998"},{"key":"e_1_2_6_3_1","first-page":"882","volume-title":"The causes of epilepsy: common and uncommon causes in adults and children","author":"Di Bonaventura C.","year":"2019"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1997.tb01098.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12799"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.2538"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00401-9"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/60.1.13"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2019.02.005"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.03.027"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2008.05.004"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1284.008"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.1966.tb06262.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13594"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2011.08.012"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2014.04.013"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2020.10.019"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1684\/epd.2021.1322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T16:12:47Z","timestamp":1710778367000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1684\/epd.2021.1322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":16,"aliases":["10.1002\/epd2.20111"],"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1684\/epd.2021.1322"],"URL":"https:\/\/doi.org\/10.1684\/epd.2021.1322","archive":["Portico"],"relation":{},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"value":"1294-9361","type":"print"},{"value":"1950-6945","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"2020-12-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}