{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:14:22Z","timestamp":1790198062877,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["KLI 969\u2010B"],"award-info":[{"award-number":["KLI 969\u2010B"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the clinical outcome of patients with possible and definitive post\u2010hypoxic status epilepticus (SE) and to describe the SE types in patients with definitive post\u2010hypoxic SE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with definitive or possible SE resulting from hypoxic brain injury after cardiac arrest (CA) were prospectively recruited. Intermittent EEG was used for the diagnosis of SE according to clinical practice. Two raters blinded to outcome analyzed EEGs retrospectively for possible and definitive SE patterns and background features (frequency, continuity, reactivity, and voltage). Definitive SE was classified according to semiology (ILAE). Mortality and Cerebral Performance Categories (CPC) score were evaluated 1\u2009month after CA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 64 patients of whom 92% died. Among the survivors, only one patient had a good neurological outcome (CPC 1). No patient survived with a burst suppression pattern, low voltage, or electro\u2010cerebral silence in any EEG. Possible or definitive SE was diagnosed in a median of 47\u2009h (IQR 39\u201372\u2009h) after CA. EEG criteria for definitive electrographic SE were fulfilled in 39% of patients; in 38% \u2013 for electroclinical SE and in 23% \u2013 for ictal\u2010interictal continuum (IIC). The outcome did not differ significantly between the three groups. The only patient with good functional outcome belonged to the IIC group. Comatose non\u2010convulsive SE (NCSE) without subtle motor phenomenon occurred in 20% of patients with definitive electrographic SE and outcome was similar to other types of SE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Possible or definitive SE due to hypoxic brain injury is associated with poor prognosis. The outcome of patients with electrographic SE, electroclinical SE, and IIC did not differ significantly. Outcome was similar in patients with definitive electrographic SE with and without prominent motor features.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epd2.20164","type":"journal-article","created":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T10:10:05Z","timestamp":1696068605000},"page":"823-832","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Post\u2010hypoxic status epilepticus \u2013 A distinct subtype of status epilepticus with poor prognosis"],"prefix":"10.1002","volume":"25","author":[{"given":"Kateriine","family":"Orav","sequence":"first","affiliation":[{"name":"Department of Neurology, Member of the European Reference Network EpiCARE, Centre for Cognitive Neuroscience, Christian Doppler University Hospital Paracelsus Medical University of Salzburg  Salzburg Austria"},{"name":"Department of Neurology North Estonia Medical Centre  Tallinn Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Bosque\u00a0Varela","sequence":"additional","affiliation":[{"name":"Department of Neurology, Member of the European Reference Network EpiCARE, Centre for Cognitive Neuroscience, Christian Doppler University Hospital Paracelsus Medical University of Salzburg  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Pr\u00fcwasser","sequence":"additional","affiliation":[{"name":"Department of Neurology, Member of the European Reference Network EpiCARE, Centre for Cognitive Neuroscience, Christian Doppler University Hospital Paracelsus Medical University of Salzburg  Salzburg Austria"},{"name":"Department of Mathematics Paris\u2010Lodron University  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7437-8992","authenticated-orcid":false,"given":"Lukas","family":"Machegger","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Christian Doppler University Hospital Paracelsus Medical University of Salzburg  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8552-6762","authenticated-orcid":false,"given":"Markus","family":"Leitinger","sequence":"additional","affiliation":[{"name":"Department of Neurology, Member of the European Reference Network EpiCARE, Centre for Cognitive Neuroscience, Christian Doppler University Hospital Paracelsus Medical University of Salzburg  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5950-2692","authenticated-orcid":false,"given":"Eugen","family":"Trinka","sequence":"additional","affiliation":[{"name":"Department of Neurology, Member of the European Reference Network EpiCARE, Centre for Cognitive Neuroscience, Christian Doppler University Hospital Paracelsus Medical University of Salzburg  Salzburg Austria"},{"name":"Neuroscience Institute Christian Doppler University Hospital  Salzburg Austria"},{"name":"Karl Landsteiner Institute for Neurorehabilitation and Space Neurology  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6899-8506","authenticated-orcid":false,"given":"Giorgi","family":"Kuchukhidze","sequence":"additional","affiliation":[{"name":"Department of Neurology, Member of the European Reference Network EpiCARE, Centre for Cognitive Neuroscience, Christian Doppler University Hospital Paracelsus Medical University of Salzburg  Salzburg Austria"},{"name":"Neuroscience Institute Christian Doppler University Hospital  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13121"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2012.11.001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000265819.36639.e0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12064"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000343006.60851.62"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13202"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02297.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2016.02.002"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001742"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002462"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2021.07.026"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06368-4"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-021-01322-0"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14607"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-022-11368-5"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2018.06.030"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2023.109745"},{"key":"e_1_2_8_19_1","unstructured":"BenderA.S1\u2010Leitlinie Hypoxisch\u2010isch\u00e4mische Enzephalopathie im Erwachsenenalter;2018."},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2023.01.002"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0000000000000806"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12270"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30137-5"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2016.08.012"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006615"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2012.01.029"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2012.03.033"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31825b94f0"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16999"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-3834-x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2016.04.008"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181eaa1e7"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-015-0215-9"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25518"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2019.04.707"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17319"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2015.04.007"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2020.07.030"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2115998"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17614"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2014.00039"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181dad5b9"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24697"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.5698\/1535-7597.17.5.265"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003470"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2018.01.027"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epd2.20164","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T12:40:45Z","timestamp":1710765645000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/epd2.20164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,10]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/epd2.20164"],"URL":"https:\/\/doi.org\/10.1002\/epd2.20164","archive":["Portico"],"relation":{},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"value":"1294-9361","type":"print"},{"value":"1950-6945","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,10]]},"assertion":[{"value":"2023-06-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}