{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:21:23Z","timestamp":1790713283157,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","award":["013400400B"],"award-info":[{"award-number":["013400400B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Automated seizure detection of focal epileptic seizures is needed for objective seizure quantification to optimize the treatment of patients with epilepsy. Heart rate variability (HRV)\u2010based seizure detection using patient\u2010adaptive threshold with logistic regression machine learning (LRML) methods has presented promising performance in a study with a Danish patient cohort. The objective of this study was to assess the generalizability of the novel LRML seizure detection algorithm by validating it in a dataset recorded from long\u2010term video\u2010EEG monitoring (LTM) in a Brazilian patient cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ictal and inter\u2010ictal ECG\u2010data epochs recorded during LTM were analyzed retrospectively. Thirty\u2010four patients had 107 seizures (79 focal, 28 generalized tonic\u2013clonic [GTC] including focal\u2010to\u2010bilateral\u2010tonic\u2013clonic seizures) eligible for analysis, with a total of 185.5\u2009h recording. Because HRV\u2010based seizure detection is only suitable in patients with marked ictal autonomic change, patients with &gt;50\u2009beats\/min change in heart rate during seizures were selected as responders. The patient\u2010adaptive LRML seizure detection algorithm was applied to all elected ECG data, and results were computed separately for responders and non\u2010responders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patient\u2010adaptive LRML seizure detection algorithm yielded a sensitivity of 84.8% (95% CI: 75.6\u201393.9) with a false alarm rate of .25\/24\u2009h in the responder group (22 patients, 59 seizures). Twenty\u2010five of the 26 GTC seizures were detected (96.2%), and 25 of the 33 focal seizures without bilateral convulsions were detected (75.8%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>The study confirms in a new, independent external dataset the good performance of seizure detection from a previous study and suggests that the method is generalizable. This method seems useful for detecting both generalized and focal epileptic seizures. The algorithm can be embedded in a wearable seizure detection system to alert patients and caregivers of seizures and generate objective seizure counts helping to optimize the treatment of the patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/epd2.20196","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T12:23:30Z","timestamp":1707481410000},"page":"199-208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Detection of seizures with ictal tachycardia, using heart rate variability and patient adaptive logistic regression machine learning methods: A hospital\u2010based validation study"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3095-2040","authenticated-orcid":false,"given":"Jesper","family":"Jeppesen","sequence":"first","affiliation":[{"name":"Department of Clinical Neurophysiology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Lin","sequence":"additional","affiliation":[{"name":"Medical Sciences Post\u2010graduate Program Federal University of Santa Catarina (UFSC)  Florian\u00f3polis SC Brazil"},{"name":"Neurology Division Federal University of Santa Catarina (UFSC)  Florian\u00f3polis SC Brazil"},{"name":"Center for Applied Neurosciences (CeNAp) Federal University of Santa Catarina (UFSC)  Florian\u00f3polis SC Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8152-7773","authenticated-orcid":false,"given":"Hiago Murilo","family":"Melo","sequence":"additional","affiliation":[{"name":"Graduate Program in Neuroscience UFSC  Florian\u00f3polis SC Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonatas","family":"Pavei","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering Federal University of Santa Catarina  Florian\u00f3polis SC Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8910-4735","authenticated-orcid":false,"given":"Jefferson Luiz Brum","family":"Marques","sequence":"additional","affiliation":[{"name":"Center for Applied Neurosciences (CeNAp) Federal University of Santa Catarina (UFSC)  Florian\u00f3polis SC Brazil"},{"name":"Institute of Biomedical Engineering Federal University of Santa Catarina  Florian\u00f3polis SC Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e1ndor","family":"Beniczky","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Clinical Neurophysiology, Danish Epilepsy Centre  Dianalund Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Walz","sequence":"additional","affiliation":[{"name":"Medical Sciences Post\u2010graduate Program Federal University of Santa Catarina (UFSC)  Florian\u00f3polis SC Brazil"},{"name":"Neurology Division Federal University of Santa Catarina (UFSC)  Florian\u00f3polis SC Brazil"},{"name":"Center for Applied Neurosciences (CeNAp) Federal University of Santa Catarina (UFSC)  Florian\u00f3polis SC Brazil"},{"name":"Graduate Program in Neuroscience UFSC  Florian\u00f3polis SC 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