{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:00:01Z","timestamp":1747148401861,"version":"3.40.5"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe a patient with acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) with unique features, including concurrent transverse myelitis. A 2\u2010year\u2010old previously healthy girl had clinical findings consistent with AESD, occurring in association with influenza A infection. The posterior brain regions were most severely affected, resulting in cortical blindness. She also developed bilateral limb weakness, and spine MRI revealed transverse myelitis in the cervical region. She was treated acutely with intravenous methylprednisolone. Serum anti\u2010myelin oligodendrocyte glycoprotein and anti\u2010aquaporin\u20104 antibodies were negative, as was an anti\u2010extractable nuclear antigen panel. Although her clinical presentation was severe, she improved dramatically over the following months, and 6 months following initial presentation, her parents felt she had returned to baseline. This is the first report of AESD occurring in combination with transverse myelitis. The co\u2010occurrence of the two conditions is unlikely to be coincidental, suggesting that there may be a shared or overlapping immunological pathway involved. The patient's recovery was impressive, which could partially relate to the acute treatment with corticosteroids.<\/jats:p>","DOI":"10.1002\/epd2.20212","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T09:15:21Z","timestamp":1709198121000},"page":"365-368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute encephalopathy with biphasic seizures and late reduced diffusion with concurrent transverse myelitis"],"prefix":"10.1002","volume":"26","author":[{"given":"Amanda","family":"Austin\u2010Keiller","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Sciences McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Saint\u2010Martin","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7831-4593","authenticated-orcid":false,"given":"Kenneth A.","family":"Myers","sequence":"additional","affiliation":[{"name":"Research Institute of the McGill University Health Centre  Montreal Quebec Canada"},{"name":"Division of Neurology, Department of Pediatrics Montreal Children's Hospital, McGill University Health Centre  Montreal Quebec Canada"},{"name":"Department of Neurology and Neurosurgery McGill University Health Centre  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2009.02.012"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2020.04.006"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix412"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2019.12.004"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2014.02.010"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/00099228221084422"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2011.07.012S0387\u20107604(11)00209\u20109[pii]"},{"key":"e_1_2_5_9_1","first-page":"295","article-title":"Acute encephalopathy with biphasic seizures and late reduced diffusion with visual disturbance and higher brain dysfunction","volume":"43","author":"Morino S","year":"2011","journal-title":"No To Hattatsu"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/1817\u20101745.111429"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.15981"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000022940"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epd2.20212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T08:35:40Z","timestamp":1717749340000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/epd2.20212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,29]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/epd2.20212"],"URL":"https:\/\/doi.org\/10.1002\/epd2.20212","archive":["Portico"],"relation":{},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"type":"print","value":"1294-9361"},{"type":"electronic","value":"1950-6945"}],"subject":[],"published":{"date-parts":[[2024,2,29]]},"assertion":[{"value":"2023-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}