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These phenotypes include faciobrachial dystonic seizures with LGI1 encephalitis, neuropsychiatric presentations associated with movement disorders and seizures in NMDA\u2010receptor encephalitis, and chronic temporal lobe epilepsy in GAD65 neurologic autoimmunity. Prompt recognition of these disorders is important, as some of them are highly responsive to immunotherapy. The response to immunotherapy is highest in patients with encephalitis secondary to antibodies targeting cell surface synaptic antigens. However, the response is less effective in conditions involving antibodies binding intracellular antigens or in Rasmussen syndrome, which are predominantly mediated by cytotoxic T\u2010cell processes that are associated with irreversible cellular destruction. Autoimmune encephalitides also may have a paraneoplastic etiology, further emphasizing the importance of recognizing these disorders. Finally, autoimmune processes and responses to novel immunotherapies have been reported in new\u2010onset refractory status epilepticus (NORSE) and febrile infection\u2010related epilepsy syndrome (FIRES), warranting their inclusion in any current review of autoimmune\u2010associated seizure disorders.<\/jats:p>","DOI":"10.1002\/epd2.20231","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T09:58:34Z","timestamp":1717149514000},"page":"415-434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Autoimmune\u2010associated seizure disorders"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8659-3801","authenticated-orcid":false,"given":"Kelsey M.","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota 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