{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:02:22Z","timestamp":1781276542420,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002301","name":"Eesti Teadusagentuur","doi-asserted-by":"publisher","award":["PRG1912"],"award-info":[{"award-number":["PRG1912"]}],"id":[{"id":"10.13039\/501100002301","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Epilepsy develops in one third of the patients after perinatal stroke. It is still unclear which vascular syndrome of ischemic stroke carries higher risk of epilepsy. The aim of the current study was to evaluate the risk of epilepsy according to the vascular syndrome of perinatal stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 39 children with perinatal arterial ischemic stroke (13 with anterior or posterior trunk of the distal middle cerebral artery occlusion, 23 with proximal or distal M1 middle cerebral artery occlusion and three with lenticulostriate arteria infarction), and 44 children with presumed perinatal venous infarction. Magnetic resonance imaging obtained at the chronic stage was used to evaluate the vascular syndrome of stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up time was 15.1\u2009years (95% CI: 12.4\u201316.5\u2009years), epilepsy developed in 19\/83 (22.9%) patients. The cumulative probability to be without epilepsy at 15\u2009years was 75.4% (95% CI: 65.8\u201386.4). The probability of having epilepsy was higher in the group of proximal or distal M1 artery occlusion compared to patients with periventricular venous infarction (HR 7.2, 95% CI: 2.5\u201326, <jats:italic>p<\/jats:italic>\u2009=\u2009.0007). Patients with periventricular venous infarction had significantly more often status epilepticus or spike\u2013wave activation in sleep \u226585% of it compared to patients with anterior or posterior trunk of the distal middle cerebral artery occlusion (OR\u2009=\u200981; 95% CI: 1.3\u20135046, <jats:italic>p<\/jats:italic>\u2009=\u2009.029).<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>The emphasis of this study is placed on classifying the vascular syndrome of perinatal stroke and on the targeted follow\u2010up of patients for epilepsy until young adulthood. The risk for having epilepsy after perinatal stroke is the highest in children with proximal or distal M1 middle cerebral artery occlusion. Patients with periventricular venous infarction have a more severe course of epilepsy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/epd2.20239","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T13:53:41Z","timestamp":1715349221000},"page":"471-483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Vascular syndrome predicts the development and course of epilepsy after perinatal stroke"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2546-1079","authenticated-orcid":false,"given":"Ulvi","family":"Vaher","sequence":"first","affiliation":[{"name":"Department of Radiology, Institute of Clinical Medicine University of Tartu  Tartu Estonia"},{"name":"Children's Clinic Tartu University Hospital  Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Ilves","sequence":"additional","affiliation":[{"name":"Department of Radiology, Institute of Clinical Medicine University of Tartu  Tartu Estonia"},{"name":"Radiology Clinic Tartu University Hospital  Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigul","family":"Ilves","sequence":"additional","affiliation":[{"name":"Department of Radiology, Institute of Clinical Medicine University of Tartu  Tartu Estonia"},{"name":"Radiology Clinic Tartu University Hospital  Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rael","family":"Laugesaar","sequence":"additional","affiliation":[{"name":"Children's Clinic Tartu University Hospital  Tartu Estonia"},{"name":"Department of Pediatrics, Institute of Clinical Medicine University of Tartu  Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mairi","family":"M\u00e4nnamaa","sequence":"additional","affiliation":[{"name":"Department of Radiology, Institute of Clinical Medicine University of Tartu  Tartu Estonia"},{"name":"Children's Clinic Tartu University Hospital  Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Loorits","sequence":"additional","affiliation":[{"name":"Radiology Clinic Tartu University Hospital  Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pille","family":"Kool","sequence":"additional","affiliation":[{"name":"Department of Radiology, Institute of Clinical Medicine University of Tartu  Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilvi","family":"Ilves","sequence":"additional","affiliation":[{"name":"Department of Radiology, Institute of Clinical Medicine University of Tartu  Tartu Estonia"},{"name":"Radiology Clinic Tartu University Hospital  Tartu 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