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Prior research has indicated the involvement of the nucleus accumbens shell (<jats:styled-content style=\"fixed-case\">NAcSh<\/jats:styled-content>) in the process of epileptogenesis, thereby implying its potential as a therapeutic target for <jats:styled-content style=\"fixed-case\">TLE<\/jats:styled-content>. In the present study, we investigated the antiepileptic effect of the <jats:styled-content style=\"fixed-case\">NAcSh<\/jats:styled-content> electrical lesion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Chronic <jats:styled-content style=\"fixed-case\">TLE<\/jats:styled-content> was induced by stereotactic injection of kainic acid (<jats:styled-content style=\"fixed-case\">KA<\/jats:styled-content>) into the hippocampus 3\u2009weeks after <jats:styled-content style=\"fixed-case\">KA<\/jats:styled-content> administration, and <jats:styled-content style=\"fixed-case\">NAcSh<\/jats:styled-content> electrical lesions were performed. Seizures in rats were monitored by video electroencephalogram (<jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>) 1\u2009week following the <jats:styled-content style=\"fixed-case\">NAcSh<\/jats:styled-content> electrical lesion. Besides, the spatial memory function assessment in rats was conducted using the Morris water maze (<jats:styled-content style=\"fixed-case\">MWM<\/jats:styled-content>) test in the final week of the experiment. Later, hippocampal glial cell activation and neuron loss in rats were evaluated through immunohistochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TLE rats subjected to NAcSh electrical lesion exhibited a significant reduction in the frequency of seizures compared to untreated TLE rats. Furthermore, NAcSh electrical lesion led to less activation of hippocampal glial cells and fewer neuronal loss in TLE rats. It is worth noting that the NAcSh electrical lesion did not cause additional memory impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>In the present study, the NAcSh electrical lesion exhibited a definitive therapeutic effect on the chronic TLE rat model, potentially due to decreased hippocampal TLE\u2010induced activation of glial cells and neuron loss. In conclusion, our results indicated that the NAcSh is a promising therapeutic target for TLE and possesses high potential for clinical application.<\/jats:p><\/jats:sec>","DOI":"10.1002\/epd2.20316","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T14:39:45Z","timestamp":1732199985000},"page":"204-218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nucleus accumbens shell electrical lesion attenuates seizures and gliosis in chronic temporal lobe epilepsy rats"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7467-6703","authenticated-orcid":false,"given":"Shuaishuai","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Institute of Brain Diseases Nanfang Hospital of Southern Medical University  Guangzhou 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