{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:23:18Z","timestamp":1792815798039,"version":"4.5.0"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We performed a systematic review of the ictal semiology of temporo\u2010frontal seizures with the aim to summarize the state\u2010of\u2010the\u2010art anatomo\u2010clinical correlations in the field, and help guide the interpretation of ictal semiology within the framework of presurgical evaluation. We conducted the systematic review and meta\u2010analysis, and reported its results according to the Preferred Reporting Items for Systematic Review and Meta\u2010Analysis statement. We searched electronic databases (Scopus, PUBMED, Web of Science, and EMBASE) using relevant keywords related to temporal, frontal and sublobar structures, semiology, and electroencephalography\/stereoelectroencephalography exploration. The risk of bias was evaluated using the QUADAS2. We included articles in English, reporting the seizure semiology of patients with temporal lobe epilepsy with temporal\u2010frontal involvement and patients with frontal lobe epilepsy and fronto\u2010temporal network involved. We performed hierarchical cluster analysis to determine signs and symptoms associated with the temporo\u2010frontal epileptogenic network for all patients and for each subgroup (frontal\/temporal seizure onset). Fisher exact test was performed to evaluate the difference in seizure freedom and clinical sign\/symptom occurrence in patients that underwent unilobar versus bilobar resection. Meta\u2010analysis on the prevalence of temporo\u2010frontal\/fronto\u2010temporal involvement applying a random\u2010effect model was used. We included 40 articles and we extracted data from 109 patients. The meta\u2010analysis showed the total prevalence of temporo\u2010frontal\/fronto\u2010temporal network involvement was 19.75%, CI 12.02\u201327.47, high heterogeneity (82.71%). For the whole group and subgroups, the main cluster of clinical manifestations is emotional, autonomic, cognitive, grimace, hyperkinetic (association coefficient higher than .6). Elementary motor semiology is significantly associated with multilobar resection (<jats:italic>p<\/jats:italic>\u2009=\u2009.022 whole group and <jats:italic>p<\/jats:italic>\u2009=\u2009.0012 fronto\u2010temporal subgroup). Fifty\u2010eight patients were seizure\u2010free after surgery. There was no significant difference between seizure freedom in uni versus bilobar resections (<jats:italic>p<\/jats:italic>\u2009=\u2009.28). Seizures involving temporo\u2010frontal\/fronto\u2010temporal network usually manifest with a cluster of signs and symptoms: emotional, autonomic, grimace, cognitive and hyperkinetic behavior. Based on semiology, one cannot distinguish between fronto\u2010temporal and temporo\u2010frontal cases at individual patient level. In those patients undergoing a surgical procedure, elementary motor seizure semiology is significantly associated with multilobar resection.<\/jats:p>","DOI":"10.1002\/epd2.20328","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T16:08:41Z","timestamp":1735229321000},"page":"171-186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Ictal semiology in temporo\u2010frontal epilepsy: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3796-0676","authenticated-orcid":false,"given":"Irina","family":"Oane","sequence":"first","affiliation":[{"name":"Neurology Department, Epilepsy Monitoring Unit University Emergency Hospital Bucharest  Bucharest 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