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Therefore, neuropsychologists need to recognize the constellation of factors that can contribute to the neurocognitive presentation of a person with epilepsy and consider these factors in the interpretation of their assessment results. In this paper, we highlight common scenarios prompting the need to account for such factors when conducting and interpreting neuropsychological assessments. To illustrate these complexities, a case study is presented of a woman with early onset epilepsy complicated by a traumatic brain injury in adulthood who was a candidate for epilepsy surgery. A discussion of the need to consider neurodevelopmental, psychiatric, and psychosocial factors in conducting an assessment and arriving at a sound interpretation of results is presented. Clinical take\u2010away points are offered for guidance in undertaking such assessments.<\/jats:p>","DOI":"10.1002\/epd2.70052","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T10:19:21Z","timestamp":1749809961000},"page":"729-744","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Diagnostic Challenges in the Neuropsychology of Epilepsy: Report of the\n                    <scp>ILAE<\/scp>\n                    Neuropsychology Task Force Diagnostic Methods Commission: 2021\u20132025"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1937-1026","authenticated-orcid":false,"given":"Mary Lou","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Psychology University of Toronto; Neurosciences and Mental Health Program, the Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Neurosciences and Mental Health Program, the 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