{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:16:22Z","timestamp":1785449782317,"version":"3.56.0"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T00:00:00Z","timestamp":1750464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201016\u2010CONV000X"],"award-info":[{"award-number":["ANR\u201016\u2010CONV000X"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201017\u2010EURE\u20100029"],"award-info":[{"award-number":["ANR\u201017\u2010EURE\u20100029"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201019\u2010CE37\u20100027"],"award-info":[{"award-number":["ANR\u201019\u2010CE37\u20100027"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007586","name":"Aix-Marseille Universit\u00e9","doi-asserted-by":"publisher","award":["AMX\u201019\u2010IET\u2010004"],"award-info":[{"award-number":["AMX\u201019\u2010IET\u2010004"]}],"id":[{"id":"10.13039\/100007586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Loss of consciousness\/awareness during temporal lobe seizures significantly affects quality of life and is closely linked to pathological thalamocortical synchronization and loss of cortical signal complexity. The medial pulvinar nucleus (PUM) contributes to seizure propagation and awareness impairment, making it a potential target for neuromodulation. Acute high\u2010frequency PUM stimulation has previously been shown to reduce seizure severity and improve awareness, potentially by disrupting excessive synchrony.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>In this study, we investigated the effects of PUM stimulation on signal complexity and its relationship to ictal awareness using permutation entropy (PE) in SEEG recordings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Eight patients with focal drug\u2010resistant temporal epilepsy underwent hippocampus\u2010induced seizures with and without additional high\u2010frequency PUM stimulation. SEEG complexity changes were quantified using PE and ictal awareness was assessed using the Consciousness Seizure Scale (CSS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our results showed that PUM stimulation attenuated entropy reductions during seizures, suggesting a preservation of neural complexity. Moreover, reduced entropy alterations correlated with improved CSS scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These findings support the role of PUM stimulation in mitigating pathological neural complexity alterations, with potential implications for preserving both consciousness and cognitive function in epilepsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Further studies are needed to confirm these findings in larger cohorts and to explore the long\u2010term effects of thalamic deep brain stimualtion in drug\u2010resistant epilepsy as well as the interaction between neural complexity, awareness, and cognition in this context.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epd2.70056","type":"journal-article","created":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T11:44:04Z","timestamp":1750506244000},"page":"1004-1010","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Modulation of neural complexity and consciousness in temporal lobe seizures: Effects of high\u2010frequency pulvinar stimulation"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8978-8927","authenticated-orcid":false,"given":"Ionu\u021b\u2010Flavius","family":"Bratu","sequence":"first","affiliation":[{"name":"Department of Epileptology and Cerebral Rhythmology Timone Hospital  Marseille France"},{"name":"Aix\u2010Marseille University, French National Institute of Health and Medical Research (UMR 1106), Systems Neuroscience Institute  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"El Youssef","sequence":"additional","affiliation":[{"name":"Department of Epileptology and Cerebral Rhythmology Timone Hospital  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislas","family":"Lagarde","sequence":"additional","affiliation":[{"name":"Department of Epileptology and Cerebral Rhythmology Timone Hospital  Marseille France"},{"name":"Aix\u2010Marseille University, French National Institute of Health and Medical Research (UMR 1106), Systems Neuroscience Institute  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Bartolomei","sequence":"additional","affiliation":[{"name":"Department of Epileptology and Cerebral Rhythmology Timone Hospital  Marseille France"},{"name":"Aix\u2010Marseille University, French National Institute of Health and Medical Research (UMR 1106), Systems Neuroscience Institute  Marseille 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