{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T15:47:56Z","timestamp":1763480876965,"version":"3.45.0"},"reference-count":8,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Unverricht\u2013Lundborg disease (ULD) is a rare, progressive myoclonic epilepsy for which no disease\u2010modifying treatments currently exist. Disease biomarkers are critically needed to guide prognosis and monitor therapeutic response. We present a case highlighting progressive deterioration of sleep architecture as a potential marker of disease progression in ULD. Quantitative EEG (qEEG) analysis over serial recordings demonstrated a gradual decline in hallmark features of non\u2010rapid eye movement sleep, including sleep spindles and K\u2010complexes. Over time, these sleep\u2010specific graphoelements became nearly absent, rendering sleep EEG patterns indistinguishable from wakefulness. This loss of sleep architecture occurred in parallel with worsening motor and cognitive function. These findings suggest that sleep EEG abnormalities may reflect underlying cortical dysfunction and could serve as an early, objective indicator of neurodegeneration in ULD. Further prospective studies are warranted to validate qEEG as a noninvasive biomarker for disease monitoring and to explore its potential role in clinical trials.<\/jats:p>","DOI":"10.1002\/epd2.70079","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T14:15:06Z","timestamp":1755872106000},"page":"1032-1037","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sleep architecture and\n                    <scp>qEEG<\/scp>\n                    patterns in\n                    <scp>PME<\/scp>\n                    type 1 diagnosis"],"prefix":"10.1002","volume":"27","author":[{"given":"Emma","family":"Pophal","sequence":"first","affiliation":[{"name":"Duke University  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4657-7417","authenticated-orcid":false,"given":"Mohamed","family":"Taha","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology University of Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Doll","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology University of Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Douglas R.","family":"Nordli","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology University of Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berge","family":"Minassian","sequence":"additional","affiliation":[{"name":"UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3995-5467","authenticated-orcid":false,"suffix":"III","given":"Douglas R.","family":"Nordli","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology University of Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2006.10.006"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0370\u20104475(74)80052\u20103"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.1990.tb06306.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0013\u20104694(96)96028\u20109"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2005.12.003"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.5935\/1984\u20100063.20220045"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022\u20103956(00)00038\u20108"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2021.101559"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epd2.70079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T15:41:08Z","timestamp":1763480468000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/epd2.70079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,22]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/epd2.70079"],"URL":"https:\/\/doi.org\/10.1002\/epd2.70079","archive":["Portico"],"relation":{},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"type":"print","value":"1294-9361"},{"type":"electronic","value":"1950-6945"}],"subject":[],"published":{"date-parts":[[2025,8,22]]},"assertion":[{"value":"2025-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}