{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:09:07Z","timestamp":1773014947050,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Cenobamate is approved for treating focal epilepsy and has potential for treating tumor\u2010related epilepsy (TRE) based on potential anti\u2010tumor effects, though there is little data on efficacy and safety in this patient population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective, multi\u2010center study of patients with TRE who were prescribed cenobamate as adjunctive treatment between January 2020 and November 2024 at Mayo Clinic in Florida, Minnesota, and Arizona. Drug efficacy was assessed, and factors that were predictive of response to treatment were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 17 patients were included, with 12 being drug resistant. The median seizure frequency for the entire group before starting cenobamate treatment was 12 (IQR\u2009=\u20094\u201364) per month, and after treatment at last follow\u2010up was 3 (IQR\u2009=\u20091\u201315) per month, with an overall 56.3% reduction. Four patients (23.5%) were seizure\u2010free, and 7 (41.1%) patients were responders (at least 50% seizure reduction). No adverse events were reported for patients on concurrent chemotherapy. Responders had significantly fewer seizures per month compared to non\u2010responders (5.72\u2009\u00b1\u200910.29 vs. 27.33\u2009\u00b1\u200930.17;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.030). No clinical factors were predictive of responsiveness (or lack thereof) to cenobamate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrates that adjunctive therapy with cenobamate treatment for TRE is a feasible and potentially effective option. Clinical history, including drug resistance, did not predict drug efficacy. No adverse effects were reported in those treated with chemotherapy. Further studies are needed to validate treatment response and safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epd2.70081","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T12:49:38Z","timestamp":1754657378000},"page":"1178-1186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of cenobamate in tumor\u2010related epilepsy"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0858-0560","authenticated-orcid":false,"given":"Guido","family":"Chiriboga","sequence":"first","affiliation":[{"name":"Mayo Clinic Alix School of Medicine  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Safa","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Florida  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anteneh","family":"Feyissa","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Florida  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Noe","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Arizona  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9763-1025","authenticated-orcid":false,"given":"David","family":"Burkholder","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed","family":"Mirsattari","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Florida  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Quinones\u2010Hinojosa","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery Mayo Clinic Florida  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Tatum","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Florida  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7446-1983","authenticated-orcid":false,"given":"Brin","family":"Freund","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Florida  Jacksonville Florida 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