{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:36:33Z","timestamp":1783042593202,"version":"3.54.6"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Neurocysticercosis (NCC) is a common parasitic infection of the central nervous system and a known cause of focal epilepsy. Its potential role in triggering or contributing to mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE\u2010HS) is suggested, but the impact on brain volumetry remains unclear. This study aimed to assess volumetric differences in the brain, with a particular focus on the hippocampus and temporal lobes, in patients with NCC, MTLE, MTLE\u2010HS, and their combinations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was an observational, cross\u2010sectional, retrospective, single\u2010center exploratory study including five groups: healthy controls; isolated MTLE; isolated NCC; MTLE\u2010HS; and MTLE\u2010HS combined with NCC (MTLE\u2010HS plus NCC). All participants had at least one magnetic resonance imaging (MRI) examination suitable for volumetric post\u2010processing. Volumetric analysis was performed on cerebral cortex regions (frontal, parietal, temporal, and occipital lobes), cerebellum, total and white matter limbic system, amygdala, hippocampus, and thalamus using the T1 MultiAtlas Segmentation tool (Brain GPS\u00a9). We also assessed sensitivity by estimating the minimum detectable difference from adjusted models and performed an exploratory analysis of NCC lesion topography with Welch\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests on lobar\/subcortical volumes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After adjusting for age and sex, no significant group differences were found in hippocampal or temporal lobe volumetrics (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u2009.10). Effect sizes were small (partial \u03b7\n                      <jats:sup>2<\/jats:sup>\n                      \u2009\u2264\u2009.10), and MANOVA confirmed the absence of a global effect (Pillai's Trace\u2009=\u2009.114,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.623). Adjusted means showed only modest variation with overlapping confidence intervals, indicating that differences likely reflect individual variability rather than systematic group effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>The findings indicate that NCC, whether isolated or combined with MTLE\u2010HS, does not cause significant alterations in brain volume. This suggests the absence of an additive or synergistic effect of NCC on brain morphostructural changes in patients with MTLE\u2010HS. These results contribute to understanding the pathophysiology of epilepsy related to NCC and hippocampal sclerosis, supporting that volumetric brain changes may not underlie their association.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epd2.70115","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T10:17:19Z","timestamp":1763115439000},"page":"109-118","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Volumetric\n                    <scp>MRI<\/scp>\n                    study of the brain in patients with neurocysticercosis and mesial temporal lobe epilepsy"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4396-2100","authenticated-orcid":false,"given":"Jaisa Quedi","family":"Ara\u00fajo","sequence":"first","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna","family":"da Silveira Arruda","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Polita","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maur\u00edcio","family":"An\u00e9s","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Junqueira Ribeiro","family":"de Rezende","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas Universidade Estadual de Campinas  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6885-8646","authenticated-orcid":false,"given":"Matheus","family":"de Lima Ruffini","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0786-5571","authenticated-orcid":false,"given":"Adolfo Moraes","family":"de Souza","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordana Soares","family":"Chaves","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2256-4379","authenticated-orcid":false,"given":"Fabiano","family":"Reis","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas Universidade Estadual de Campinas  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marino Muxfeldt","family":"Bianchin","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4973-2889","authenticated-orcid":false,"given":"Juliana \u00c1vila","family":"Duarte","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul  Porto Alegre 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