{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:32:04Z","timestamp":1773012724050,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Surgery is the treatment of choice in drug\u2010resistant temporal lobe epilepsy (TLE). The estimated seizure freedom after anterior temporal lobectomy and amygdalo\u2010hippocampectomy (ATL\u2010AH) is 70%\u201380%. Accurate identification of the epileptogenic zone by prompt presurgical evaluation reduces surgical failures. Our study aims to assess the utility of intraoperative electrocorticography (iECoG) in improving seizure outcomes following ATL\u2010AH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled patients with drug\u2010resistant TLE who underwent ATL\u2010AH from January 2009 to December 2018. They were followed up at 3\u2009months, 12\u2009months and annually for assessment of seizure recurrence. Post\u2010resection ECoG findings were classified into (1) no\/rare residual epileptiform discharges and (2) less than 50% reduction in discharges. Post\u2010operative outcome was deemed \u201cgood\u201d if seizure\u2010free and aura\u2010free during the entire period of post\u2010operative follow\u2010up and \u201cpoor\u201d if there is a recurrence of auras and\/or seizures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 684 patients enrolled, 566 had \u201cgood\u201d outcomes and 118 had \u201cpoor\u201d outcomes. Resection was ECoG\u2010guided in 545 patients. Less than 50% reduction in spikes on post\u2010resection ECoG was found in 133 patients. There was no significant difference in seizure outcomes based on ECoG guidance (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.65) or clearance of spikes on post\u2010resection ECoG (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.13). iECoG was not done in 139 (20.3%) patients due to technical glitches during the procedure or due to affordability issues.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Utility of iECoG in tailoring resection margins is limited and it does not predict seizure outcome after ATL\u2010AH. In centers where ATL\u2010AH is ECoG\u2010guided, it is advisable to abandon this time\u2010consuming procedure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epd2.70141","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:42:06Z","timestamp":1764938526000},"page":"155-164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Does intraoperative electrocorticography alter seizure outcomes after temporal lobe epilepsy surgery?"],"prefix":"10.1002","volume":"28","author":[{"given":"Soumya V.","family":"Chandrasekharan","sequence":"first","affiliation":[{"name":"Department of Neurology, R. Madhavan Nayar Center for Comprehensive Epilepsy Care Sree Chitra Tirunal Institute for Medical Sciences and Technology  Trivandrum Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayakumari","family":"Nandana","sequence":"additional","affiliation":[{"name":"Department of Neurology, R. Madhavan Nayar Center for Comprehensive Epilepsy Care Sree Chitra Tirunal Institute for Medical Sciences and Technology  Trivandrum Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0972-3307","authenticated-orcid":false,"given":"Ramshekhar N.","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Neurology, R. Madhavan Nayar Center for Comprehensive Epilepsy Care Sree Chitra Tirunal Institute for Medical Sciences and Technology  Trivandrum Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Vilanilam","sequence":"additional","affiliation":[{"name":"Department of Neurology, R. Madhavan Nayar Center for Comprehensive Epilepsy Care Sree Chitra Tirunal Institute for Medical Sciences and Technology  Trivandrum Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathew","family":"Abraham","sequence":"additional","affiliation":[{"name":"Department of Neurology, R. Madhavan Nayar Center for Comprehensive Epilepsy Care Sree Chitra Tirunal Institute for Medical Sciences and Technology  Trivandrum Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bejoy","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Neurology, R. Madhavan Nayar Center for Comprehensive Epilepsy Care Sree Chitra Tirunal Institute for Medical Sciences and Technology  Trivandrum Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandrashekharan","family":"Kesavadas","sequence":"additional","affiliation":[{"name":"Department of Neurology, R. Madhavan Nayar Center for Comprehensive Epilepsy Care Sree Chitra Tirunal Institute for Medical Sciences and Technology  Trivandrum Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nandini","family":"Vijayambika Sadasivan Nair","sequence":"additional","affiliation":[{"name":"Department of Neurology, R. Madhavan Nayar Center for Comprehensive Epilepsy Care Sree Chitra Tirunal Institute for Medical Sciences and Technology  Trivandrum Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashalatha","family":"Radhakrishnan","sequence":"additional","affiliation":[{"name":"Department of Neurology, R. Madhavan Nayar Center for Comprehensive Epilepsy Care Sree Chitra Tirunal Institute for Medical Sciences and Technology  Trivandrum Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01732.x"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.10.1505"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh449"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1227\/neu.0000000000002358"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2018.04.013"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.37803.x"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2018.08.006"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12747"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2012.03.008"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0404.2003.00183.x"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1042-3680(18)30593-X"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.12.2259"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S031716710000072X"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1059-1311(03)00095-5"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2009.12.007"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2016.02.047"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.3171\/2020.4.PEDS20198"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2017.11.020"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13008"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.2176\/jns-nmc.2022-0252"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ons\/opab019"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.3171\/2018.11.JNS182124"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.33588\/rn.3309.2000628"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0000000000000376"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17472"},{"key":"e_1_2_14_27_1","unstructured":"SchueleS HusainA TatumW GavvalaJ SelioutskiO SinhaS et\u00a0al.ACNS technical standards for performing intraoperative electrocorticography."},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.3171\/2012.8.JNS12258"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-3019(96)00277-7"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00311-8"},{"key":"e_1_2_14_31_1","first-page":"77","article-title":"Electrocorticography for the evaluation of focus resection","volume":"51","author":"Inaji M","year":"2023","journal-title":"No Shinkei Geka"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2022.12.003"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epd2.70141","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/epd2.70141","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epd2.70141","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:15:13Z","timestamp":1773008113000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/epd2.70141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,5]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/epd2.70141"],"URL":"https:\/\/doi.org\/10.1002\/epd2.70141","archive":["Portico"],"relation":{},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"value":"1294-9361","type":"print"},{"value":"1950-6945","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,5]]},"assertion":[{"value":"2025-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}