{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T07:40:17Z","timestamp":1776325217261,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>For mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE with HS), laser interstitial thermal therapy has recently been increasingly used. At our institute, however, selective amygdalohippocampectomy by a trans\u2010anterior T1 subpial approach (trans\u2010anterior T1 SAH) has been used for MTLE with HS. Here, we examined the seizure, neuropsychological, and quality of life (QOL) outcomes after trans\u2010anterior T1 SAH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred patients with MTLE with HS who underwent trans\u2010anterior T1 SAH and were followed for at least 1\u2009year after surgery were included. Seizure outcomes, intelligence and memory, visual field changes evaluated by perimetry, and QOL were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seizure\u2010free outcome (Engel class I) at the latest follow\u2010up (mean 4.6\u2009years) was achieved in 88\/100 (88%) patients. Only 1 of 100 patients underwent intracranial EEG. Postoperative contralateral upper quadrantanopia was detected in only 15\/73 (21%) of patients. Significant improvements in full\u2010scale IQ, verbal IQ, and performance IQ, as examined by the Wechsler Adult Intelligence Scale\u2010III, were seen in both the language\u2010dominant\u2010side surgery and the language\u2010nondominant\u2010side surgery groups. In patients who underwent language\u2010dominant\u2010side SAH, significant declines in general memory and verbal memory scores on the Wechsler memory scale \u2013 revised edition were observed at a group level. Significant improvement in attention\/concentration was seen regardless of the surgical side. QOL analysis revealed that approximately 30% of patients felt their memory declined after surgery; however, half of the patients felt that being free to go out and become employed was an advantage, and about 90% of patients were satisfied with their surgical treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Trans\u2010anterior T1 SAH led to favorable seizure outcomes in about 90% of patients with MTLE with HS. Most patients were pleased with their surgery. In patients with MTLE with HS, the preferred surgical strategy should still be SAH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epd2.70157","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T14:31:57Z","timestamp":1765981917000},"page":"389-400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mesial temporal lobe epilepsy with hippocampal sclerosis: Seizure, neuropsychological, and quality of life outcomes of 100 patients treated with trans\u2010anterior\n                    <scp>T1<\/scp>\n                    selective amygdalohippocampectomy"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9736-7460","authenticated-orcid":false,"given":"Naotaka","family":"Usui","sequence":"first","affiliation":[{"name":"National Epilepsy Center, NHO Shizuoka Institute of Epilepsy and Neurological Disorders  Shizuoka 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