{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:57:08Z","timestamp":1787500628007,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Patients with drug\u2010resistant epilepsy (DRE) typically take multiple anti\u2010seizure medications (ASMs) and are at risk of treatment\u2010related adverse events (AEs). This study assessed the impact of cenobamate monotherapy or dual therapy in patients with drug\u2010resistant epilepsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a multicenter (six Spanish epilepsy units), retrospective, observational study in patients with drug\u2010resistant epilepsy who had received treatment with cenobamate as monotherapy (after conversion from polytherapy) or in dual therapy for at least three consecutive months, between April 2017 and November 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 125 patients (mean age 46\u2009\u00b1\u200915.9\u2009years; median epilepsy duration 16\u2009years, range: 1\u201365) were included. Median follow\u2010up was 11\u2009months (range 3\u201380). Patients had received a median of 5 (range 2\u201319) previous anti\u2010seizure medications and were receiving a median of 2 (range 0\u20133) concomitant anti\u2010seizure medications at cenobamate initiation; the most common concomitant anti\u2010seizure medications were lacosamide (36%), brivaracetam (29.6%), and clobazam (26.4%). The median cenobamate dose at the last visit was 200 mg\/day (range 100\u2013400\u2009mg\/day). By the last visit, 31.5% of patients had achieved seizure freedom, and 75.8%, 58.1%, and 49.2% had achieved \u226550%, \u226575%, and \u226590% reductions in seizure frequency, respectively. During cenobamate treatment, 52% of patients discontinued one, 32% discontinued two, and 4% discontinued three concomitant anti\u2010seizure medications. In total, 63\/125 patients (50.4%) had adverse events during cenobamate treatment, all mild or moderate; 40.8% of patients had adverse events at the last visit. The most reported adverse events were somnolence (22.4%), dizziness (10.4%), fatigue (7.2%), and instability (4.8%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>This study highlights the real\u2010world effectiveness and safety of cenobamate, either as monotherapy (after conversion from polytherapy) or in dual therapy, in patients with drug\u2010resistant epilepsy. Cenobamate allows for a significant treatment simplification, resulting in fewer treatment\u2010related adverse events without compromising seizure reduction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epd2.70222","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T09:55:23Z","timestamp":1774605323000},"page":"775-785","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness and safety of cenobamate after conversion to monotherapy or dual therapy in real\u2010world clinical practice"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7023-0710","authenticated-orcid":false,"given":"\u00c1lvaro S\u00e1nchez\u2010Guijo","family":"Benavente","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA\u2010Plataforma Bionand)  M\u00e1laga Spain"},{"name":"Hospital Regional 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