{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T11:23:35Z","timestamp":1787397815749,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate risk factors affecting the short\u2010 and long\u2010term prognosis of pediatric status epilepticus (SE) complicated by nonconvulsive status epilepticus (NCSE) during the disease course and to analyze the clinical heterogeneity of this group to effectively identify population characteristics and subgroups influencing prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study is a single\u2010center retrospective cohort study. Clinical data from 215 pediatric patients diagnosed with SE at Chongqing Medical University Children's Hospital between February 2005 and September 2024, who met the diagnostic criteria for NCSE during their illness, were included. Univariate analysis and multivariate logistic regression were employed to identify factors associated with short\u2010term and long\u2010term adverse outcomes. Hierarchical cluster analysis was conducted based on clinical characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The in\u2010hospital mortality rate was 3.3% (7\/215), increasing to 6.0% (12\/200) in long\u2010term follow\u2010up. The short\u2010term poor prognosis rate was 29.8% (64\/215), while the long\u2010term poor prognosis rate was 20.5% (41\/200). Multivariate analysis revealed that independent risk factors for poor short\u2010term prognosis included GCS scores of 3\u20138, global developmental delay, interictal EEG showing periodic discharges, and diffuse MRI abnormalities. Poor long\u2010term prognosis was primarily associated with GCS scores of 3\u20138, global developmental delay, and electroclinical syndromes. Further clinical phenotype clustering analysis revealed four heterogeneous subgroups: super\u2010refractory subgroup (characterized by profound impaired consciousness and diffuse brain injury), young\u2010age metabolic subgroup (age\u2009&lt;\u200924\u2009months with multifocal abnormalities), focal structural subgroup (manifesting as focal neurological deficits and structural etiology), and benign reactive subgroup (mild altered consciousness and treatment sensitivity).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Level of consciousness, electroencephalogram (EEG), neurodevelopmental status, and electroclinical syndromes can serve as core indicators for prognostic stratification in children with NCSE; subtyping based on clinical features can effectively distinguish heterogeneous subgroups, providing a clinical phenotypic basis for individualized stratified diagnosis, treatment, and prognostic assessment of pediatric NCSE, thereby addressing the current lack of a multidimensional stratification framework in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epd2.70244","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T08:59:07Z","timestamp":1775638747000},"page":"1106-1121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Disease spectrum of nonconvulsive status epilepticus in children: A study based on clinical subtype characteristics and prognostic stratification"],"prefix":"10.1002","volume":"28","author":[{"given":"Lianqin","family":"Mo","sequence":"first","affiliation":[{"name":"Department of Neurology Children\u2019s Hospital of Chongqing Medical University  Chongqing China"},{"name":"National Clinical Research Center for Child Health and Disorders (Chongqing)  Chongqing China"},{"name":"Ministry of Education Key Laboratory of Child Development and Disorders  Chongqing China"},{"name":"Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Children\u2019s Hospital of Chongqing Medical University  Chongqing China"},{"name":"National Clinical Research Center for Child Health and Disorders (Chongqing)  Chongqing China"},{"name":"Ministry of Education Key Laboratory of Child Development and Disorders  Chongqing China"},{"name":"Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology Children\u2019s Hospital of Chongqing Medical University  Chongqing China"},{"name":"National Clinical Research Center for Child 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