{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T10:04:00Z","timestamp":1779876240785,"version":"3.53.1"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["NU23\u201004\u201000209"],"award-info":[{"award-number":["NU23\u201004\u201000209"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["NU23\u201008\u201000528"],"award-info":[{"award-number":["NU23\u201008\u201000528"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["NW25\u201004\u201000427"],"award-info":[{"award-number":["NW25\u201004\u201000427"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["00064203"],"award-info":[{"award-number":["00064203"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","award":["666320"],"award-info":[{"award-number":["666320"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate outcomes in relation to epilepsy characteristics and genetic findings in pediatric patients with isolated low\u2010grade epilepsy\u2010associated tumors (LEAT) and LEAT plus focal cortical dysplasia type IIIb (FCD IIIb) who underwent epilepsy surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients younger than 19\u2009years at the time of surgery, with isolated LEAT or LEAT plus FCD IIIb, and a minimum follow\u2010up of 2\u2009years were included. Clinical, neuroimaging, EEG, neuropsychological, surgical, histopathological, and molecular\u2010genetic data were analyzed. Outcomes and potential predictors were assessed across four domains: seizures, antiseizure medication (ASM) use, cognition (Full Scale Intelligence Quotient, FS\u2010IQ), and postoperative surgical complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010one children fulfilled the inclusion criteria. Fifty\u2010one (71.8%) had drug\u2010resistant epilepsy. LEAT plus FCD IIIb were more frequent (43\/71, 60.6%) than isolated LEAT (28\/71, 39.4%). Gangliogliomas were the most common tumor type (39\/71, 54.9%), followed by dysembryoplastic neuroepithelial tumors (16\/71, 22.5%). Genetic testing demonstrated internal tandem duplication of the\n                      <jats:italic>FGFR1<\/jats:italic>\n                      gene in most isolated LEAT cases (OR 11.9, 95% CI 1.32\u2013100,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.02), while LEAT+FCD IIIb cases were more frequently negative (OR 3.8, 95% CI 1.3\u201310.9,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.02). After a median 5.7\u2010year follow\u2010up, 64 patients (90.1%) were seizure\u2010free, and 55 (77.5%) discontinued ASM. Earlier seizure onset, longer epilepsy duration, and a higher number of ASM correlated with lower pre\u2010 and postoperative FS\u2010IQ. A postoperative FS\u2010IQ gain of &gt;15 points occurred in four patients (7.7%). Two patients (2.8%) had unexpected permanent deficits, and 10 (14.1%) had minor temporary deficits.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Epilepsy surgery leads to high rates of freedom from seizures and ASM in pediatric patients with LEAT and LEAT + FCD IIIb. Early surgical intervention can be associated with higher pre\u2010 and postoperative FS\u2010IQ. Molecular\u2010genetic findings suggest distinct neoplastic and dysplastic entities of LEAT and LEAT plus FCD IIIb.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epd2.70251","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T09:26:51Z","timestamp":1779874011000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Electroclinical characteristics, genetic findings, and complex epilepsy surgery outcomes in children with low\u2010grade epilepsy\u2010associated tumors: A comprehensive view"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4184-0321","authenticated-orcid":false,"given":"Gonzalo Alonso","family":"Ramos Rivera","sequence":"first","affiliation":[{"name":"Second Faculty of Medicine Charles University  Prague Czech Republic"},{"name":"Department of Neurology Bory Hospital  Bratislava 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Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7026-8238","authenticated-orcid":false,"given":"Alice","family":"Maulisov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology Motol University Hospital, Full Member of the ERN EpiCARE and Epilepsy Research Centre Prague \u2010 EpiReC Consortium  Prague Czech Republic"},{"name":"Department of Psychology, Faculty of Arts Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate\u0159ina","family":"Buka\u010dov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology Motol University Hospital, Full Member of the ERN EpiCARE and Epilepsy Research Centre Prague \u2010 EpiReC Consortium  Prague Czech 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