{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T11:23:36Z","timestamp":1787397816491,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the extent to which seizure control and the occurrence of fetal malformation in an initial pregnancy can serve to anticipate the outcome in the next pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed the records of the Raoul Wallenberg Australian Register of Antiepileptic Drugs in Pregnancy for seizure control and fetal malformation data for women with epilepsy taking antiseizure medication in consecutive pregnancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seizure freedom rates throughout pregnancy were higher in the subsequent pregnancy than in the initial one (60.8% vs. 52.9%; RR 1.15, 95% CI 1.03, 1.28), particularly when the nature of antiseizure therapy was unchanged between pregnancies. Fetal malformation occurrence rates (5.9% and 6.2%, respectively) were similar, but tended to be higher in women with generalized rather than focal epilepsies (7.9% vs. 4.28%; RR 1.84, 95% CI 0.89, 3.81). If a small cohort with fetal malformations in both the initial and subsequent pregnancies (7 women, 8 pairs of pregnancies) was excluded, the RR value was smaller (1.24). All but one woman in this cohort had generalized epilepsies. The birth of a malformed baby tended to occur more frequently in the next pregnancy for women with generalized epilepsy and a malformed baby in the previous pregnancy than in similar women with focal epilepsies (50% vs. 7.7%; RR 6.5, 95% CI 0.92, 45.1).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Compared with women with focal epilepsies, antiseizure medication\u2010treated women with generalized epilepsy who give birth to a malformed baby appear to have a substantially greater risk of another malformed baby in their next pregnancy. Overall, seizure freedom rates were higher in subsequent pregnancies than in initial ones.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epd2.70265","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T09:42:21Z","timestamp":1778838141000},"page":"1211-1220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The outcomes of consecutive pregnancies in Australian women with epilepsy"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5570-7538","authenticated-orcid":false,"given":"Frank","family":"Vajda","sequence":"first","affiliation":[{"name":"Departments of Medicine and Neurosciences The Royal Melbourne Hospital, the University of Melbourne  Parkville Victoria Australia"},{"name":"Department of Neuroscience The School of Translational Medicine, Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence J.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Department of Neuroscience The School of Translational Medicine, Monash University  Melbourne Victoria Australia"},{"name":"Department of Neurology Alfred Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Graham","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Neurosciences The Royal Melbourne Hospital, the University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Hitchcock","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Neurosciences The Royal Melbourne Hospital, the University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Perucca","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Neurosciences The Royal Melbourne Hospital, the University of Melbourne  Parkville Victoria Australia"},{"name":"Department of Neuroscience The School of Translational Medicine, Monash University  Melbourne Victoria Australia"},{"name":"Department of Neurology Alfred Health  Melbourne Victoria Australia"},{"name":"Department of Medicine Austin Health, the University of Melbourne  Heidelberg Victoria Australia"},{"name":"Bladin\u2010Berkovic Comprehensive Epilepsy Program, Austin Health  Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilie","family":"Lander","sequence":"additional","affiliation":[{"name":"Royal Brisbane and Women's Hospital and School of Medicine and Biomedical Science, University of Queensland  Brisbane Queensland 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Institute of Health and Welfare.https:\/\/www.aihw.gov.au\/reports\/mothers\u2010babies\/congenital\u2010anomalies\u2010in\u2010australia\/contents\/congenital\u2010anomalies\u2010in\u2010australia"}],"container-title":["Epileptic 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