{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T16:36:17Z","timestamp":1792859777708,"version":"4.5.0"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Super\u2010refractory status epilepticus (SRSE) is a neurological emergency with high morbidity and mortality. Cenobamate, a novel antiseizure medication, may be helpful in managing SRSE, but evidence is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective case series reports the use of cenobamate as add\u2010on therapy in the management of three cases of SRSE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median age at status epilepticus (SE) onset was 28\u2009years (range 27\u201375). The etiologies of SRSE included one case of febrile infection\u2010related epilepsy syndrome (FIRES), one patient with a probable genetic etiology (SCN7A variant of uncertain significance), and one case of unknown etiology. Cenobamate was introduced at a median of 27\u2009days (range 13\u2013103) after SE onset. Resolution of SRSE was observed after a median of 7\u2009days (range 3\u201330) once cenobamate was started. Median dose of cenobamate at SRSE cessation was 25\u2009mg\/day\u00a0(range 12.5\u201350\u2009mg\/day), and the median maintenance dose at the time of discharge was 200\u2009mg\/day (range 100\u2013400\u2009mg\/day). Two patients died\u00a0and one patient achieved functional independence. No severe medication side effects, specifically drug reaction with eosinophilia and systemic symptoms (DRESS), were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Cenobamate may have a role in the management of SRSE. Further studies are needed to define the optimal timing of initiation, titration strategy, and target dose of cenobamate in the context of SE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epd2.70270","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T10:55:46Z","timestamp":1783162546000},"page":"1661-1668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cenobamate use in super\u2010refractory status epilepticus: A\u00a0report of three cases"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6016-3141","authenticated-orcid":false,"given":"Marina","family":"Romozzi","sequence":"first","affiliation":[{"name":"Dipartimento di Neuroscienze Universit\u00e0 Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome Italy"},{"name":"Neurologia Unit\u00e0 Operativa Complesse, Dipartimento di Neuroscienze, Organi di Senso e Torace Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3143-965X","authenticated-orcid":false,"given":"Juan Luis","family":"Alcala\u2010Zermeno","sequence":"additional","affiliation":[{"name":"Comprehensive Epilepsy Center, Department of Neurology Columbia University Irving Medical Center, New York Presbyterian Hospital  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6134-5268","authenticated-orcid":false,"given":"Antonio","family":"Funcis","sequence":"additional","affiliation":[{"name":"Dipartimento di Neuroscienze Universit\u00e0 Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome Italy"},{"name":"Neurologia Unit\u00e0 Operativa Complesse, Dipartimento di Neuroscienze, Organi di Senso e Torace Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Tosto","sequence":"additional","affiliation":[{"name":"Dipartimento di Neuroscienze Presidio Ospedaliero Giovanni Paolo II  Lamezia Terme Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Piccioli","sequence":"additional","affiliation":[{"name":"Neurologia Unit\u00e0 Operativa Complesse Presidio Ospedaliero San Filippo Neri Hospital, ASL Roma 1  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3598-0195","authenticated-orcid":false,"given":"Luigi Francesco","family":"Iannone","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Maviglia","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Dell'Emergenza, Anestesiologiche e Della Rianimazione Fondazione Policlinico Universitario Agostino Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0192-5430","authenticated-orcid":false,"given":"Masahito","family":"Katsuki","sequence":"additional","affiliation":[{"name":"Headache Center, Department of Neurology Tominaga Hospital  Osaka Japan"},{"name":"Insight Science Foundation Ireland Research Centre for Data Analytics, School of Human and Health Performance Dublin City University  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Matsumori","sequence":"additional","affiliation":[{"name":"Sendai Headache and Neurology Clinic  Sendai 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