{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T16:36:20Z","timestamp":1792859780796,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Epilepsies presenting with lateral occipital seizures (LOS) pose diagnostic challenges due to their rarity and association with complex visual symptoms. We performed a systematic review to characterize the ictal semiology, electroencephalographic, imaging, and surgical features of LOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature search was conducted between 1990 and March 2024 to identify patient\u2010level studies reporting focal seizures originating from the occipital lobe, confirmed whenever possible by invasive EEG, MRI lesion, and postoperative outcome. Cases with occipital semiology due to propagation from extra\u2010occipital onset zones were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 105 abstracts were considered resulting in 13 articles reviewed, and 248 patients were analyzed. Visual symptoms were present in 8%\u201388% of patients: visual hallucinations and illusions, and oculomotor disturbances being the most frequent manifestations. Oculomotor signs, including eye deviation and eyelid myoclonia, were common but non\u2010specific for lateralization. Scalp EEG frequently demonstrated false lateralization, and only a median of 23% of patients underwent invasive monitoring. LOS originating from the lateral occipital cortex exhibited propagation along ventral and dorsal streams, accounting for associated temporal, parietal, and frontal manifestations. MRI lesions were present in 75%\u201379% of patients, including focal cortical dysplasia, tumors, and cavernomas. Surgical resection yielded Engel class I outcomes in 22%\u201370% of cases, with pediatric patients demonstrating higher seizure\u2010free rates. Postoperative visual deficits occurred in 17%\u201380% of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>LOS represent a clinically and anatomically distinct form of occipital epilepsy. Their hallmark semiology reflects lateral extrastriate cortical activation and propagation through ventral and dorsal pathways. Accurate localization requires integration of semiology, multimodal imaging, and invasive EEG. Tailored surgical interventions achieve favorable seizure outcomes, particularly in pediatric populations, while careful mapping is essential to preserve visual function. Future studies should refine lateral versus mesial occipital differentiation and optimize surgical planning through advanced imaging and electrophysiology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epd2.70292","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T14:39:47Z","timestamp":1780929587000},"page":"1444-1453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anatomo\u2010clinical correlations in patients with lateral occipital seizures: A systematic review"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8454-7374","authenticated-orcid":false,"given":"Mathilde","family":"Chipaux","sequence":"first","affiliation":[{"name":"Pediatric Neurosurgery Department CCMR Epilepsies Rares, European Reference Network EpiCare Member, Rothschild Foundation Hospital  Paris France"},{"name":"Sorbonne Universit\u00e9, Institut du Cerveau\u2010Paris Brain Institute\u2010ICM, Inserm, CNRS, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9113-6254","authenticated-orcid":false,"given":"Rayann","family":"Checri","sequence":"additional","affiliation":[{"name":"Pediatric Neurosurgery Department CCMR Epilepsies Rares, European Reference Network EpiCare Member, Rothschild Foundation Hospital  Paris France"},{"name":"Sorbonne Universit\u00e9, Institut du Cerveau\u2010Paris Brain Institute\u2010ICM, Inserm, CNRS, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re  Paris France"},{"name":"Unit\u00e9 de Recherche 3450 DevAH, D\u00e9veloppement, Adaptation et Handicap, Campus Brabois\u2010Sant\u00e9, Universit\u00e9 de Lorraine  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3651-8706","authenticated-orcid":false,"given":"Emmanuel","family":"Raffo","sequence":"additional","affiliation":[{"name":"Pediatric Neurosurgery Department CCMR Epilepsies Rares, European Reference Network EpiCare Member, Rothschild Foundation Hospital  Paris France"},{"name":"Unit\u00e9 de Recherche 3450 DevAH, D\u00e9veloppement, Adaptation et Handicap, Campus Brabois\u2010Sant\u00e9, Universit\u00e9 de Lorraine  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2009.01.008"},{"issue":"876","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1098\/rspb.1947.0017","article-title":"Some observations on the cerebral cortex of man","volume":"134","author":"Penfield W","year":"1947","journal-title":"Proceedings of the Royal Society of London \u2010 Series B: Biological Sciences"},{"key":"e_1_2_10_4_1","unstructured":"PenfieldW.Epilepsy and the functional anatomy of the human brain.1954London By W. Penfield \u2026 And Herbert Jasper \u2026 Chapter XIV by Francis McNaughton Etc. [with plates and a bibliography.] printed in U.S.A. 896."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh458"},{"key":"e_1_2_10_6_1","first-page":"496","volume-title":"Neurosurgical operative atlas","author":"Rengachary SS","year":"1991"},{"key":"e_1_2_10_7_1","first-page":"1032","volume-title":"Carpenter's human neuroanatomy","author":"Parent A","year":"1996"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(92)90344-8"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.163.3870.895"},{"key":"e_1_2_10_10_1","first-page":"549","volume-title":"Analysis of visual behavior","author":"Ungerleider LG","year":"1982"},{"key":"e_1_2_10_11_1","first-page":"173","article-title":"Occipital lobe epilepsies","volume":"84","author":"Blume WT","year":"2000","journal-title":"Advances in Neurology"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410310103"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/epd2.70004"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2018.1000"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2022.06.001"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3171\/2008.4.17490"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2024.10.012"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2005.70904.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2008.11.008"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2011.12.015"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2005.56604.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1993.tb02590.x"}],"container-title":["Epileptic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epd2.70292","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/epd2.70292","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epd2.70292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:44:58Z","timestamp":1792856698000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/epd2.70292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,8]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/epd2.70292"],"URL":"https:\/\/doi.org\/10.1002\/epd2.70292","archive":["Portico"],"relation":{},"ISSN":["1294-9361","1950-6945"],"issn-type":[{"value":"1294-9361","type":"print"},{"value":"1950-6945","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,8]]},"assertion":[{"value":"2025-10-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}