{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:21:19Z","timestamp":1783506079774,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R279\u20102018\u20101145"],"award-info":[{"award-number":["R279\u20102018\u20101145"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n Depression is common in mesial temporal lobe epilepsy (mTLE), but its neuroanatomical basis\u2014and overlap with major depressive disorder (MDD)\u2014remains poorly defined. We investigated whether the cortical and subcortical alterations reported in MDD are also present in mTLE and leveraged the frequent occurrence of depression after epilepsy surgery to test whether such changes predate the onset of post\u2010surgical depression.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Eighty\u2010nine mTLE patients scheduled for anterior temporal lobectomy were classified as never depressed (NoD,\n n<\/jats:italic>\n \u2009=\u200942), depressed before surgical evaluation (PreD,\n n<\/jats:italic>\n \u2009=\u200923), or developing de\u2010novo depression after surgery (PostD,\n n<\/jats:italic>\n \u2009=\u200922). Pre\u2010operative 3\u2009T MRI (1\u2009mm\u2009T1, T2, FLAIR) was processed with FreeSurfer v6.3. Six frontotemporal\u2010limbic regions showing the largest MDD effects in ENIGMA studies\u2014orbitofrontal cortex, rostral anterior cingulate, insula, fusiform gyrus, hippocampus, posterior cingulate\u2014were analyzed using a latent variable model.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Depression status significantly influenced combined morphology in both hemispheres (\n p<\/jats:italic>\n \u2009<\u20090.05). Relative to NoD, both PreD and PostD groups showed reduced cortical thickness in the orbitofrontal cortex, fusiform gyrus, insula, and rostral anterior cingulate (Cohen's d\u2009=\u2009\u22120.04 to \u22120.14). Hippocampal volume and posterior cingulate thickness did not differ between groups.\n <\/jats:p>\n <\/jats:sec>\n \n Significance<\/jats:title>\n Four of the six frontotemporal regions showing the largest morphometric alterations in MDD also exhibit reduced cortical thickness in mTLE patients with past or future depression. This shared frontotemporal thinning pattern supports depression in mTLE as an expression of network pathology common to MDD, while residual regional differences may help explain the distinct phenotypic presentations of depression in these neuropsychiatric disorders. In PostD patients, these abnormalities were already present pre\u2010operatively, consistent with a pre\u2010existing vulnerability rather than a purely psychosocial reaction to surgery or epilepsy per se.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/epd2.70297","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:07:58Z","timestamp":1783505278000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preoperative limbic cortical thinning in mesial temporal lobe epilepsy surgical candidates is associated with pre\u2010existing and de novo postoperative depression"],"prefix":"10.1002","author":[{"given":"Philip","family":"Fink\u2010Jensen","sequence":"first","affiliation":[{"name":"Neurobiology Research Unit, Department of Neurology Copenhagen University Hospital Rigshospitalet Copenhagen 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Copenhagen, Mental Health Services, Capital Region of Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6035-6581","authenticated-orcid":false,"given":"Sandor","family":"Beniczky","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"},{"name":"Department of Neurophysiology Danish Epilepsy Center Dianalund Denmark"},{"name":"Department of Neurophysiology Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Ganz","sequence":"additional","affiliation":[{"name":"Neurobiology Research Unit, Department of Neurology Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"},{"name":"Department of Computer Science University of Copenhagen Copenhagen 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