{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T14:31:32Z","timestamp":1793716292490,"version":"4.6.1"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201016\u2010CONV000X"],"award-info":[{"award-number":["ANR\u201016\u2010CONV000X"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201017\u2010EURE\u20100029"],"award-info":[{"award-number":["ANR\u201017\u2010EURE\u20100029"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The postictal state is a major yet underrecognized component of the epilepsy burden. We aimed to develop a structured patient\u2010reported instrument to quantify postictal recovery, characterize its multidimensional burden, and identify demographic, clinical, psychiatric, and treatment\u2010related factors associated with postictal severity and duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective, single\u2010center observational cohort study (Timone Hospital, Marseille, February 2025\u2013March 2026). Consecutive patients aged \u226515\u2009years admitted for scalp or stereo\u2010EEG video\u2010monitoring were included. Patients completed the Postictal Recovery Scale (PRS), an 11\u2010domain questionnaire assessing fatigue, mood, sensory, motor, language, orientation, time perception, and postictal amnesia. Items were rated from 0 (severe impairment) to 3 (no symptoms), yielding a total score of 0\u201333. Internal consistency was assessed using Cronbach's alpha. Associations between PRS scores, subjective postictal duration and covariates were analyzed using group comparisons, correlations, and regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 107 enrolled patients, 96 were included. PRS showed good internal consistency (Cronbach's \u03b1\u2009=\u20090.79). 96% of patients reported experiencing postictal symptoms, with fatigue (80%) and postictal amnesia (79%) being the most frequent and severe manifestations. Recovery exceeded 1\u2009h in 21% of patients. Greater postictal impairment was associated with higher interictal anxiety (Spearman \u03c1\u2009=\u2009\u22120.32,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0018) and depressive symptoms (Spearman \u03c1\u2009=\u2009\u22120.40,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0001), whereas demographic, epilepsy\u2010related, and treatment variables showed no significant associations. Altered postictal time perception was reported by 40% of patients and was associated with disorientation, but not postictal psychiatric symptoms. Subjective postictal duration was longer than subjective ictal duration (Wilcoxon test,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>The postictal state is a frequent and multidimensional patient\u2010reported experience. Greater postictal severity, particularly concerning anxiety and depression, is associated with interictal psychiatric comorbidity, while altered temporal experience emerges as a distinct dimension of postictal dysfunction. These findings support integrating postictal measures into clinical practice and trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epd2.70340","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T15:24:50Z","timestamp":1783783490000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The burden of the postictal state in epilepsy: A prospective, single\u2010center observational cohort study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8978-8927","authenticated-orcid":false,"given":"Ionu\u021b\u2010Flavius","family":"Bratu","sequence":"first","affiliation":[{"name":"Department of Epileptology and Cerebral Rhythmology Timone Hospital  Marseille France"},{"name":"Systems Neuroscience Institute, Aix\u2010Marseille University, French National Institute of Health and Medical Research (UMR 1106)  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8632-3454","authenticated-orcid":false,"given":"Agn\u00e8s","family":"Tr\u00e9buchon","sequence":"additional","affiliation":[{"name":"Department of Epileptology and Cerebral Rhythmology Timone Hospital  Marseille France"},{"name":"Systems Neuroscience Institute, Aix\u2010Marseille University, French National Institute of Health and Medical Research (UMR 1106)  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1678-0297","authenticated-orcid":false,"given":"Fabrice","family":"Bartolomei","sequence":"additional","affiliation":[{"name":"Department of Epileptology and Cerebral Rhythmology Timone Hospital  Marseille France"},{"name":"Systems Neuroscience Institute, Aix\u2010Marseille University, French National Institute of Health and Medical Research (UMR 1106)  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,11]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12550"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.YEBEH.2010.06.038"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.YEBEH.2019.03.014"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ANA.27307"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/epd2.70175"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CLINPH.2023.03.202"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/S10548\u2010022\u201000930\u2010Z\/METRICS"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/EPI.16519"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ACN3.52073"},{"key":"e_1_2_13_11_1","unstructured":"BratuI LambertI Tramoni\u2010NegreE Medina VillalonS Tr\u00e9buchonA BartolomeiF.Postictal Burden in the Hippocampus is Associated with Long\u2010Term Memory Consolidation Impairment. 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