{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:53:26Z","timestamp":1791359606420,"version":"4.3.1"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy\u2010related mortality, yet its mechanisms remain complex and multifactorial. Cardiac repolarization abnormalities are proposed biomarkers, but evidence is scarce, especially in low\u2010 and middle\u2010income countries where epilepsy is highly prevalent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross\u2010sectional case\u2010control study including 73 adults with epilepsy and 73 age\u2010 and sex\u2010matched controls. Participants with cardiovascular risk factors or medications affecting QTc were excluded. All subjects underwent 24 h Holter ECG, and QTc values were categorized using standard cutoffs. Clinical, electroencephalographic, radiological, and therapeutic data were collected. SUDEP risk was evaluated using the SUDEP\u20107 inventory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with epilepsy had significantly longer QTc intervals than controls (mean QTc 474.1 vs. 432.9\u2009ms,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001\n                      <jats:italic>)<\/jats:italic>\n                      . QTc prolongation was more frequent in patients (47.9% vs. 15.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), and highly abnormal QTc values (&gt;500\u2009ms) occurred only in the epilepsy group (6.8%). The SUDEP\u20107 score correlated positively with QTc duration (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.462,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). Several factors were significantly associated with QTc prolongation: longer disease duration (OR\u2009=\u20091.10; 95% CI: 1.02\u20131.18;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), carbamazepine use (OR\u2009=\u20092.08; 95% CI: 1.20\u20133.61;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009), and polytherapy (OR\u2009=\u20091.81; 95% CI: 1.10\u20132.95;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019). Higher seizure burden (\u22653 GTCS\/year) was strongly associated with longer QTc (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). No significant association was found between sex, seizure type, and QTc prolongation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>QTc prolongation is frequent in people with epilepsy and correlates with SUDEP\u20107 scores, supporting its potential value as a simple, noninvasive marker of SUDEP risk. Routine ECG monitoring, particularly in patients with established risk factors, may help identify individuals at higher risk of SUDEP and guide preventive strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epd2.70418","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:34:36Z","timestamp":1791358476000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiac repolarization abnormalities and\n                    <scp>SUDEP<\/scp>\n                    risk in epilepsy"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3821-640X","authenticated-orcid":false,"given":"Hakim","family":"Farah","sequence":"first","affiliation":[{"name":"Neurology Department Habib Bourguiba University Hospital  Sfax Tunisia"},{"name":"Laboratory of Neurogenetics, Parkinson's Disease and Cerebrovascular Disease (LR\u201012\u2010SP\u201019) Habib Bourguiba 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Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haddar","family":"Asma","sequence":"additional","affiliation":[{"name":"Department of Physiology and Functional Exploration Habib Bourguiba University Hospital  Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7743-5553","authenticated-orcid":false,"given":"Sakka","family":"Salma","sequence":"additional","affiliation":[{"name":"Neurology Department Habib Bourguiba University Hospital  Sfax Tunisia"},{"name":"Laboratory of Neurogenetics, Parkinson's Disease and Cerebrovascular Disease (LR\u201012\u2010SP\u201019) Habib Bourguiba University Hospital, University of Sfax  Sfax Tunisia"},{"name":"Clinical Investigation Center Habib Bourguiba University Hospital  Sfax 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