{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:52:24Z","timestamp":1791903144494,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To develop and externally validate a nomogram for predicting in\u2010hospital mortality in ICU patients with SE, using readily available clinical data collected within the first 24\u2009h of ICU admission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We identified adult SE patients from MIMIC\u2010IV (training cohort, 2008\u20132019) using ICD\u20109\/ICD\u201010 codes. Twenty\u2010seven candidate predictors were screened by LASSO logistic regression with 10\u2010fold cross\u2010validation. The final model was constructed with multivariable logistic regression and presented as a nomogram. Internal validation used 1000 bootstrap resamples with optimism correction. External validation was performed in an independent SE cohort from the eICU\u2010CRD database (2014\u20132015).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The training cohort comprised 299 patients (69 deaths, 23.1% mortality). LASSO selected nine predictors: age, first ICU care unit, Glasgow Coma Scale, temperature, SpO\n                      <jats:sub>2<\/jats:sub>\n                      , white blood cell count, glucose, bicarbonate, and the Elixhauser comorbidity index. The optimism\u2010corrected AUC was .807 (95% CI, .754\u2013.860) with a Brier score of .124. External validation in 597 eICU patients yielded an AUC of .750 (95% CI, .685\u2013.815). In sensitivity analyses, a reduced model without the comorbidity score achieved an optimism\u2010corrected AUC of .786 and an external AUC of .730, and a model without the ICU care\u2010unit type achieved .817 and .764, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>This nine\u2010variable nomogram provides a validated, bedside\u2010applicable tool for mortality risk stratification in ICU SE patients, enabling manual risk calculation without electronic computation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epd2.70437","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:32:26Z","timestamp":1791901946000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and external validation of a nomogram for predicting in\u2010hospital mortality in status epilepticus patients in the intensive care unit: A\n                    <scp>MIMIC<\/scp>\n                    \u2010\n                    <scp>IV<\/scp>\n                    and\n                    <scp>eICU<\/scp>\n                    \u2010\n                    <scp>CRD<\/scp>\n                    study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1706-7872","authenticated-orcid":false,"given":"Yin","family":"Fangzhao","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Huanhu Hospital, Tianjin University  Tianjin Jinnan China"},{"name":"Brain Medical Center, Tianjin University  Tianjin Jinnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8605-9609","authenticated-orcid":false,"given":"Wang","family":"Yudan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tianjin Chest Hospital  Tianjin Jinnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Deqiu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Huanhu Hospital, Tianjin University  Tianjin Jinnan China"},{"name":"Brain Medical Center, Tianjin University  Tianjin Jinnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"issue":"6","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S1474-4422(15)00042-3","article-title":"Status epilepticus in adults","volume":"14","author":"Betjemann JP","year":"2015","journal-title":"Lancet Neurol"},{"issue":"8","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1001\/archneurol.2010.169","article-title":"Frequency and prognosis of convulsive status epilepticus of different causes: a systematic review","volume":"67","author":"Neligan A","year":"2010","journal-title":"Arch 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