{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:38:06Z","timestamp":1792665486935,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Meteorological conditions have been investigated as potential short\u2010term correlates of epileptic seizures, but findings remain inconsistent. This study examined whether daily meteorological variation was associated with population\u2010level online information\u2010seeking for epilepsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A daily time\u2010series study was conducted in Lombardy, Italy, from September 1, 2021, to September 2, 2026. The primary outcome was a reconstructed daily Google Trends series for the Topic\n                      <jats:italic>Epilessia<\/jats:italic>\n                      (epilepsy). Daily mean sea\u2010level pressure and 2\u2010m temperature derived from ERA5 were the primary exposures. Distributed lag nonlinear models evaluated cumulative associations over lags 0\u20137\u2009days, adjusting for long\u2010term and seasonal trends, day of week, and national holidays. Newey\u2010West standard errors accounted for residual autocorrelation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 1822\u2009days with complete exposure histories, lower mean sea\u2010level pressure (5th percentile, 1003.5\u2009hPa) versus the median (1016.8\u2009hPa) was associated with higher cumulative epilepsy\u2010related search activity (difference, 8.98\u2009units; 95% confidence interval [CI], 1.66\u201316.31;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016). No clear associations were observed at higher pressure levels or at low or high temperature. The association remained evident in several prespecified sensitivity analyses, including a log\u2010transformed outcome, but was attenuated in the positive\u2010only analysis and was not replicated using the simple search term\n                      <jats:italic>epilessia<\/jats:italic>\n                      . Secondary analyses showed no clear associations for relative humidity or precipitation, but an inverse association with high wind speed was found.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lower mean sea\u2010level pressure was associated with increased population\u2010level epilepsy\u2010related Google search activity. The observed association corresponded to a 13.3\u2010hPa reduction in atmospheric pressure, a difference commonly encountered during the passage of low\u2010pressure weather systems. Although the direction of the association is broadly consistent with some studies reporting increased seizure occurrence during periods of lower atmospheric pressure, Google Trends reflects information\u2010seeking behavior rather than clinical outcomes. Therefore, these findings should be regarded as hypothesis\u2010generating and should not be interpreted as evidence that atmospheric pressure influences seizure occurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epd2.70447","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:41:32Z","timestamp":1792662092000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Atmospheric pressure, temperature, and online search activity for epilepsy: A daily time\u2010series study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0928-1577","authenticated-orcid":false,"given":"Francesco","family":"Brigo","sequence":"first","affiliation":[{"name":"Innovation, Research and Teaching Service, Teaching Hospital of the Paracelsus Medical Private University (PMU) Azienda Sanitaria dell'Alto Adige  Bolzano\u2010Bozen Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2025.110667"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2019.04.036"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13776"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40572\u2010024\u201000466\u20103"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883\u2010021\u201002535\u20108"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2024.119495"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2015.12.017"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2013.11.020"},{"key":"e_1_2_12_10_1","unstructured":"Istituto nazionale di statistica Istat.\u201cBilancio demografico mensile e popolazione residente per sesso anno 2026 \u201d2026.https:\/\/demo.istat.it\/app\/?i=D7B"},{"key":"e_1_2_12_11_1","volume-title":"Low\u2010pressure area (weather system)","author":"Sheposh R","year":"2021"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2007.01111.x"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2009.06.023"},{"issue":"4","key":"e_1_2_12_14_1","first-page":"227","article-title":"Impact of weather on prevalence of febrile seizures in children","volume":"26","author":"Joo HW","year":"2018","journal-title":"J Korean Child Neurol 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