{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T17:20:49Z","timestamp":1776100849549,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A20393"],"award-info":[{"award-number":["U21A20393"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study was undertaken to assess whether periconceptional folic acid (FA) supplementation affects seizures, maternal, and fetal outcomes in Chinese women with epilepsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included pregnant women with epilepsy enrolled in the West China Pregnancy Registry of Epilepsy between 2012 and 2021. Detailed data on maternal health, FA intake, antiseizure medications (ASMs), pregnancy, and perinatal outcomes were obtained during regular visits to neurology clinics. Primary outcomes were seizure control status and adverse maternal and fetal outcomes. To adjust for potential confounders, subgroup and sensitivity analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 1638 pregnancies of 1405 women with epilepsy. A total of 1299 (79.3%) pregnancies in 1173 women used FA supplements during periconception, and 1351 (82.5%) pregnancies were exposed to ASMs. The recurrence rate of convulsive seizures was significantly higher among non\u2010FA users compared with FA users throughout pregnancy. Low FA dose, delayed initiation, and short use duration were associated with an increased risk of seizures during pregnancy. Most pregnancies (78.8%) in the non\u2010FA group were lost compared to 13% in the FA group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). Non\u2010FA users had 3.5\u2010fold and 7.5\u2010fold increased risks of spontaneous and elective abortions compared with FA users. The protective effect was more prevalent among those using ASMs. Pregnancies exposed to low\u2010dose FA had higher rates of adverse maternal\u2013fetal outcomes than those receiving medium\u2010 to high\u2010dose FA supplements.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Periconceptional FA intake by women with epilepsy was associated with an approximately 66% decreased risk of abortion and improved seizure control during pregnancy. Low\u2010dose FA may be insufficient to prevent adverse maternal\u2013fetal outcomes in this population. Further studies are warranted to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70093","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T15:21:02Z","timestamp":1768404062000},"page":"1722-1736","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of folic acid supplementation on seizures, maternal and fetal outcomes in pregnant Chinese women with epilepsy"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3333-4800","authenticated-orcid":false,"given":"Ammar T.","family":"Abdulaziz","sequence":"first","affiliation":[{"name":"Department of Neurology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanya","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Neurology West China Hospital, Sichuan University  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Monash University, Alfred Hospital  Melbourne Victoria Australia"},{"name":"Department of Neurology School of Translational Medicine, Monash University, Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6041-9661","authenticated-orcid":false,"given":"Josemir W.","family":"Sander","sequence":"additional","affiliation":[{"name":"Department of Neurology West China Hospital, Sichuan University  Chengdu China"},{"name":"Epilepsy Department UCL Queen Square Institute of Neurology  London UK"},{"name":"Research Unit, Chalfont Centre for Epilepsy  Chalfont St. Peter UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7411-8269","authenticated-orcid":false,"given":"Jinmei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology West China Hospital, Sichuan University  Chengdu China"},{"name":"Department of Neurology Shangjin 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