{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:04:26Z","timestamp":1792591466714,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006546","name":"Angelini Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006546","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015050","name":"Sociedad Espa\u00f1ola de Epilepsia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Cenobamate is an antiseizure medication (ASM) with proven effectiveness in individuals with highly refractory epilepsy. This study investigated the effectiveness and tolerability of cenobamate in different treatment lines and a less refractory setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a multicenter, retrospective, observational study. Adults with focal epilepsy, 2\u20136 prior ASMs, and \u226512\u2009months between cenobamate initiation and database closure were included. Data from patients' charts were collected and included in the Drug\u2010Resistant Epilepsy Registry of the Spanish Epilepsy Society using Research Electronic Data Capture. Primary effectiveness endpoints included changes in seizure frequency at 3, 6, and 12\u2009months after cenobamate initiation according to different treatment lines. Primary safety endpoints included the percentage of patients with adverse events (AEs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 486 patients were included (mean age 42.8\u2009years). The mean number of prior ASMs was 4.4 (2\u20136); the mean number of concomitant ASMs at cenobamate initiation was 2.5 (1\u20135). At 12\u2009months, treatment retention was 92% and median dose was 200\u2009mg. One\u2010year seizure\u2010freedom rates were 32.5%, 33.3%, 21.4%, 24.2%, and 11.4% in those treated with 2\u20136 prior ASMs, respectively. The proportions of patients achieving \u226550%, \u226575%, \u226590%, and 100% reductions in seizure frequency at 12\u2009months were significantly higher in patients with 2\u20133 (earlier treatment lines) vs 4\u20136 prior ASMs (later treatment lines;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u2009.004). Improvements in seizure severity were reported in 71.9% of patients during follow\u2010up (82.5% and 62.1% in those with 2 and 6 prior ASMs, respectively). At 12\u2009months, 56.4% of patients had reported AEs, with somnolence the most frequent, and 4.9% had AEs requiring cenobamate discontinuation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Cenobamate was effective and well tolerated in patients who had tried 2\u20136 prior ASMs in a real\u2010world setting. High effectiveness was confirmed at 1 year, with better outcomes in earlier users.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70106","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T10:02:48Z","timestamp":1769594568000},"page":"2177-2189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Freedon study: Real\u2010life outcomes of cenobamate in different lines of treatment"],"prefix":"10.1002","volume":"67","author":[{"given":"Vicente","family":"Villanueva","sequence":"first","affiliation":[{"name":"Department of Neurology, Member of ERN EPICARE Hospital Universitario y Polit\u00e9cnico La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Serratosa","sequence":"additional","affiliation":[{"name":"Department of Neurology and Instituto de Investigaci\u00f3n Sanitaria\u2010Fundaci\u00f3n Jim\u00e9nez D\u00edaz Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Universidad Aut\u00f3noma de Madrid (IIS\u2010FJD, UAM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8383-163X","authenticated-orcid":false,"given":"Alejandro","family":"Fern\u00e1ndez\u2010Cabrera","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Universitario Lucus Augusti  Lugo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Toledo","sequence":"additional","affiliation":[{"name":"Department of Neurology Vall d'Hebron University Hospital and Vall d'Hebron Research Institute (VHIR)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Gonz\u00e1lez\u2010Gir\u00e1ldez","sequence":"additional","affiliation":[{"name":"Department of Neurology and Instituto de Investigaci\u00f3n Sanitaria\u2010Fundaci\u00f3n Jim\u00e9nez D\u00edaz Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Universidad Aut\u00f3noma de Madrid (IIS\u2010FJD, UAM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5960-8457","authenticated-orcid":false,"given":"Jos\u00e9 C.","family":"Estevez","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Universitario Reina Sof\u00eda  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5354-1256","authenticated-orcid":false,"given":"Juan Jes\u00fas","family":"Rodr\u00edguez Uranga","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centro de Neurolog\u00eda Avanzada Sevilla  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Machio Castell\u00f3","sequence":"additional","affiliation":[{"name":"Department of Neurology and Instituto de Investigaci\u00f3n 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