{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:22:52Z","timestamp":1790522572736,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study was undertaken to assess the relationship between the severity of depression and anxiety symptoms and epilepsy\u2010related variables and cognitive burden in people with epilepsy (PwE), as assessed using EpiTrack.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We prospectively enrolled a cohort of PwE who underwent EpiTrack and evaluation by Generalized Anxiety Disorder\u20107 (GAD\u20107) and Beck Depression Inventory\u2010II (BDI\u2010II) scales. We assessed the correlation strength between EpiTrack, GAD\u20107, BDI\u2010II, and the other clinical variables. Analysis of variance and covariance assessed the existence of GAD\u20107\/BDI\u2010II differences between PwE with and without epilepsy\u2010related cognitive impairment. Hierarchical regression analysis (HRA) and logistic regression were performed to characterize the association between BDI\u2010II and GAD\u20107 and the presence\/severity of epilepsy\u2010related cognitive burden. Mediation analysis was performed to evaluate the relationship between EpiTrack and the other variables applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We enrolled 100 PwE (42\u2009\u00b1\u200918\u2009years old). EpiTrack inversely correlated with BDI\u2010II (\u2212.33,\n                      <jats:italic>p<\/jats:italic>\n                      = .003, not with GAD\u20107), seizures (\u2212.34,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; .001), epileptiform abnormalities (34,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; .001), and pharmacological burden (.21,\n                      <jats:italic>p<\/jats:italic>\n                      = .002). BDI\u2010II correlated with seizure frequency (.27,\n                      <jats:italic>p<\/jats:italic>\n                      = .02). PwE with cognitive impairment had significantly higher BDI\u2010II scores, independently of age, seizure frequency, epileptiform abnormalities, and pharmacological load (\n                      <jats:italic>p<\/jats:italic>\n                      = .02\u2013.04). BDI\u2010II effect on EpiTrack was independent from seizures. The addition of BDI\u2010II in HRA and logistic regression provided a significant increase of the\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      value (\n                      <jats:italic>p<\/jats:italic>\n                      = .004) and of area under the curve (\n                      <jats:italic>p<\/jats:italic>\n                      = .02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>\n                      More severe depressive symptoms are strongly associated with worse cognitive performance in PwE,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/context.reverso.net\/traduzione\/inglese-italiano\/independently+of\">independently of<\/jats:ext-link>\n                      the other epilepsy\u2010related variables. Depressive symptoms could either forecast the occurrence of epilepsy\u2010related cognitive impairment or arise as a consequence of cognitive dysfunction in PwE. We confirmed the association between epilepsy severity and epilepsy\u2010related cognitive impairment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70108","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T10:08:11Z","timestamp":1769594891000},"page":"2425-2439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Depressive symptoms as independent correlates of epilepsy\u2010related cognitive burden"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9624-6854","authenticated-orcid":false,"given":"Biagio Maria","family":"Sancetta","sequence":"first","affiliation":[{"name":"Research Unit of Neurology, Department of Medicine and Surgery Universit\u00e0 Campus Bio\u2010Medico di Roma  Rome 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