{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:55:13Z","timestamp":1792292113864,"version":"4.4.0"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006687","name":"Universit\u00e9 Claude Bernard Lyon 1","doi-asserted-by":"publisher","award":["AAP ETOILES 2023"],"award-info":[{"award-number":["AAP ETOILES 2023"]}],"id":[{"id":"10.13039\/501100006687","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Attention impairments are common in children with epilepsy and widely impact their quality of life. Interictal epileptiform discharges (IEDs) may induce subtle dysfunctions of various cognitive processes, but data regarding the impact of IEDs on sustained attention remain limited. The objective of the present study was to evaluate the impact of IEDs on continuous undivided attention in children with epilepsy, controlling for the number of treatments, type of epilepsy, frequency of seizures in the past year, age at onset, and comorbid attention disorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using a computerized sustained attention test synchronized with the electroencephalogram in 61 children with diverse epilepsy syndromes, reaction time (RT), errors, attention stability over time, and the event\u2010related potential (ERP) in Pz (related to attentional engagement) were collected. The cumulative impact of IEDs was evaluated using multivariate models controlling for epilepsy\u2010related factors. The transient impact of IEDs was assessed by comparing responses in trials with and without IEDs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>IEDs were associated with attention fluctuations independently from other epilepsy\u2010related factors. In terms of cumulative impact, a higher IED rate was associated with a poorer sustained attention performance over the entire task. In terms of transient impact, trials disrupted by IEDs were characterized by longer RT and a lower amplitude of the ERP extending over a long time window that included attentional processing (P300).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>These results suggest that IEDs may negatively impact sustained attention, independently of other epilepsy\u2010related features. These findings support the hypothesis that IEDs could contribute to subtle attentional deficits and serve as potential biomarkers of abnormal brain function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70112","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T13:46:43Z","timestamp":1770990403000},"page":"2494-2505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Interictal epileptiform discharges are involved in momentary lapses of attention in children with epilepsy"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9763-2802","authenticated-orcid":false,"given":"Marine","family":"Thieux","sequence":"first","affiliation":[{"name":"Centre de Recherche en Neurosciences de Lyon INSERM U1028, CNRS UMR\u20105292, Universit\u00e9 Claude Bernard Lyon 1  Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Bouet","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Neurosciences de Lyon INSERM U1028, CNRS UMR\u20105292, Universit\u00e9 Claude Bernard Lyon 1  Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9274-0086","authenticated-orcid":false,"given":"Julien","family":"Jung","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Neurosciences de Lyon INSERM U1028, CNRS UMR\u20105292, Universit\u00e9 Claude Bernard Lyon 1  Bron France"},{"name":"Service de Neurologie Fonctionnelle et d'\u00c9pileptologie, Hospices Civils de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Kahane","sequence":"additional","affiliation":[{"name":"Service d'Exploration Fonctionnelle du Syst\u00e8me Nerveux, CHU Grenoble Alpes  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Vercueil","sequence":"additional","affiliation":[{"name":"Service d'Exploration Fonctionnelle du Syst\u00e8me Nerveux, CHU Grenoble Alpes  Grenoble France"},{"name":"Laboratoire de Psychologie et NeuroCognition CNRS, Universit\u00e9 Grenoble Alpes, Universit\u00e9 Savoie\u2010Mont Blanc  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Martinet","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Neurosciences de Lyon INSERM U1028, CNRS UMR\u20105292, Universit\u00e9 Claude Bernard Lyon 1  Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Perrone\u2010Bertolotti","sequence":"additional","affiliation":[{"name":"Laboratoire de Psychologie et NeuroCognition CNRS, Universit\u00e9 Grenoble Alpes, Universit\u00e9 Savoie\u2010Mont Blanc  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Philippe","family":"Lachaux","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Neurosciences de Lyon INSERM U1028, CNRS UMR\u20105292, Universit\u00e9 Claude Bernard Lyon 1  Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julitta","family":"de Bellescize","sequence":"additional","affiliation":[{"name":"Service d'\u00c9pileptologie Clinique, des Troubles du Sommeil et de Neurologie Fonctionnelle de L'enfant, Hospices Civils de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vania","family":"Herbillon","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Neurosciences de Lyon INSERM U1028, CNRS UMR\u20105292, Universit\u00e9 Claude Bernard Lyon 1  Bron France"},{"name":"Service d'\u00c9pileptologie Clinique, des Troubles du Sommeil et de Neurologie Fonctionnelle de L'enfant, Hospices Civils de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14549"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12939"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(04)00906-8"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/107.1.293"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2012.05.010"},{"issue":"1","key":"e_1_2_11_7_1","first-page":"1","article-title":"Impaired executive function by interictal epileptiform discharges in patients with idiopathic generalized epilepsy","volume":"3","author":"Yubao J","year":"2017","journal-title":"Epilepsy J"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13633"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx143"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-018-0892-9"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207531"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17781"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17365"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2019.106470"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1727"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2006.00545.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2019.107151"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2007.04.019"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10309-018-0218-6"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2016.02.016"},{"key":"e_1_2_11_22_1","volume-title":"R: a language and environment for statistical computing","author":"R Core Team","year":"2021"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_2_11_24_1","unstructured":"LenthRV.emmeans: Estimated marginal means aka least\u2010squares means.2024."},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.15191.2"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781315370279"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmal.2023.100079"},{"key":"e_1_2_11_28_1","unstructured":"RijJV WielingM BaayenRH vanRijnD.itsadug: Interpreting time series and autocorrelated data using GAMMs.2015."},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2013.07.014"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2015.0739"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2016.07.009"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03491.x"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13479"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucli.2011.11.004"},{"key":"e_1_2_11_35_1","doi-asserted-by":"crossref","unstructured":"CaggiaI BouetR JungJ LachauxJ\u2010P Ostrowsky\u2010CosteK BellescizeJD et\u00a0al.Early age at seizure onset is a risk factor for attention deficit hyperactivity disorder in children with epilepsy [Internet]. medRxiv2025. Available from:http:\/\/medrxiv.org\/lookup\/doi\/10.1101\/2025.03.21.25324382","DOI":"10.1016\/j.yebeh.2025.110577"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17334"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-5597(98)00027-6"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504136102"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn755"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-025-00924-3"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhab192"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz269"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu214"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23356"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00427.x"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00951.x"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20323"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42971-3"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410230205"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.2.318"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epi.70112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/epi.70112","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epi.70112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T11:50:12Z","timestamp":1778932212000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/epi.70112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,13]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/epi.70112"],"URL":"https:\/\/doi.org\/10.1002\/epi.70112","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,13]]},"assertion":[{"value":"2025-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}