{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T12:17:14Z","timestamp":1792844234906,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Posttraumatic stress disorder (PTSD) is more prevalent in epilepsy than in the general population. However, it remains unclear whether this association is specific to epilepsy or a broader consequence of experiencing unpredictable acute episodes within chronic diseases. This study aimed to (1) compare PTSD prevalence and severity in patients with drug\u2010resistant epilepsy (DRE) and patients with other chronic episodic diseases, namely, type 1 diabetes (T1D) and drug\u2010resistant atrial fibrillation (AF); and (2) examine psychiatric comorbidities, emotion regulation, and quality of life across groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 122 patients (64 with DRE; 58 with chronic diseases: 30 with AF, 28 with T1D) completed questionnaires assessing PTSD symptoms, trauma exposure, anxiety, depression, dissociation, emotion regulation, and quality of life. Statistical analyses included \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      tests,\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests, analyses of covariance controlling for age, and correlation analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PTSD was significantly more prevalent in the DRE group (34.94%) than in the chronic disease group (12.07%; \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20099.5,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.004). DRE patients also reported significantly more repeated trauma exposures (54.69% vs. 27.59%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.004). Compared to other groups, DRE patients showed higher anxiety (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.002), depression (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.002), and dissociation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), poorer emotion regulation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.003), and lower quality of life (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Our findings suggest that the psychiatric burden observed in DRE cannot be solely attributed to chronic episodic disease status. Instead, it may reflect the impact of early and repeated traumatic exposures and their interaction with the neurobiological underpinnings of epilepsy. The strong association between complex trauma, psychiatric comorbidities, and poor quality of life supports the hypothesis of psychoepileptogenesis and calls for integrated trauma\u2010informed care in epilepsy management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70113","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T11:10:52Z","timestamp":1769253052000},"page":"2440-2449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Is posttraumatic stress disorder specific to drug\u2010resistant epilepsy or a common feature of chronic disease? A comparative study with atrial fibrillation and type 1 diabetes"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9689-4920","authenticated-orcid":false,"given":"Lisa\u2010Dounia","family":"Soncin","sequence":"first","affiliation":[{"name":"Laboratoire d'Anthropologie et de Psychologie Cliniques, Cognitives et Sociales Universit\u00e9 C\u00f4te d'Azur  Nice France"},{"name":"Institut de Neurosciences des Syst\u00e8mes INSERM, Aix Marseille Universit\u00e9  Marseille France"},{"name":"Epileptology and Cerebral Rhythmology APHM, H\u00f4pital de la Timone  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Capucine","family":"Rodet","sequence":"additional","affiliation":[{"name":"Institut de Neurosciences des Syst\u00e8mes INSERM, Aix Marseille Universit\u00e9  Marseille 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