{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T12:16:46Z","timestamp":1778933806373,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the prevalence and possible causes of amygdala enlargement in patients with drug\u2010resistant temporal lobe epilepsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients were retrospectively identified via a radiology information system and a large language model. Magnetic resonance imaging scans were visually re\u2010analyzed and amygdala volumetry applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The term \u201camygdala\u201d was used in 89 of 1853 patients. Of those, 54 had lesions in the amygdalae, 20 had isolated amygdala enlargements, and 15 patients had amygdala enlargements and remote epileptogenic lesions. Objective processing of imaging data confirmed higher amygdala volumes of both latter groups (2.09\u2009\u00b1\u20090.28\u2009mL, 2.23\u2009\u00b1\u20090.33\u2009mL vs 1.56\u2009\u00b1\u20090.22\u2009mL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>When amygdala enlargement occurs with remote epileptogenic lesions and patients become seizure\u2010free after remote lesion resection, amygdala enlargement is likely the consequence of seizures, but not their cause. In addition, isolated amygdala enlargements can be the consequence of epileptic seizures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70139","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T07:27:18Z","timestamp":1770362838000},"page":"2389-2399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Amygdala enlargement associated with remote epileptogenic lesions"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7264-4807","authenticated-orcid":false,"given":"Horst","family":"Urbach","sequence":"first","affiliation":[{"name":"Department of Neuroradiology, Medical Center \u2013 University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5869-1110","authenticated-orcid":false,"given":"Theo","family":"Demerath","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Medical Center \u2013 University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5881-6043","authenticated-orcid":false,"given":"Alexander","family":"Rau","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Medical Center \u2013 University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8610-2216","authenticated-orcid":false,"given":"Dirk\u2010Matthias","family":"Altenm\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Epileptology, Medical Center \u2013 University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5545-7014","authenticated-orcid":false,"given":"Marcel","family":"Heers","sequence":"additional","affiliation":[{"name":"Department of Epileptology, Medical Center \u2013 University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3796-5709","authenticated-orcid":false,"given":"Samer","family":"Elsheikh","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Medical Center \u2013 University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.9.1245"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.165860"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.206342"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2013.00166"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2013.08.022"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-014-0194-z"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12968"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13471"},{"key":"e_1_2_14_10_1","first-page":"2081","article-title":"Volumetry of Mesiotemporal structures reflects serostatus in patients with limbic encephalitis","volume":"40","author":"Ernst L","year":"2019","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2019.11.015"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17968"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00062-023-01265-3"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00569-X"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.04.046"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00401-9"},{"key":"e_1_2_14_17_1","doi-asserted-by":"crossref","DOI":"10.1212\/WN9.0000000000000010","article-title":"Association of Amygdala and Hippocampus Volumes with Histopathological Diagnosis in patients with temporal lobe epilepsy","volume":"1","author":"Heers M","year":"2025","journal-title":"Neurology Open"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-018-2109-y"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12220"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.70225"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.16.16963"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2016.04.015"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2017.02.019"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epi.70139","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/epi.70139","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epi.70139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T11:51:09Z","timestamp":1778932269000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/epi.70139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,5]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/epi.70139"],"URL":"https:\/\/doi.org\/10.1002\/epi.70139","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,5]]},"assertion":[{"value":"2025-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}