{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T12:14:23Z","timestamp":1778933663576,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This work was undertaken to study the association between vagus nerve stimulation (VNS) parameters and the apnea\u2013hypopnea index (AHI) measured by polysomnography in patients with drug\u2010resistant epilepsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with epilepsy who underwent polysomnography with an active VNS device between 2018 and 2023 were retrospectively included. VNS output current and cycle speed, defined as the interval between two stimulation\u2010ON (Stim\u2010ON) periods, were correlated with AHI. Demographic, clinical, and polysomnography characteristics were compared between patients with low (\u22641.5\u2009mA) or high (&gt;1.5\u2009mA) output current, and between patients with slow VNS cycle (interval between two Stim\u2010ON of &gt;108\u2009s) and fast cycle (interval between two Stim\u2010ON of \u2264108\u2009s). Multiadjusted linear regression analysis was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010two patients were included. Output current significantly correlated with AHI, but no difference was found between patients with low versus high output current. Patients with a fast VNS cycle had a significantly higher AHI than patients with a slow VNS cycle. After adjustment for age, number of antiseizure medications, body mass index, and gender, only the cycle speed remained significant, with no significant association with output current.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Cycle speed, defined as a short interval between two stimulations, is associated with increased sleep\u2010related respiratory events in patients with epilepsy treated with VNS. Increasing the duration between two stimulations may help clinicians to reduce VNS\u2010induced sleep\u2010related breathing disorder.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70147","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T11:57:52Z","timestamp":1770983872000},"page":"2347-2357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fast cycle of vagus nerve stimulation is associated with increased sleep\u2010related breathing disorder in patients with epilepsy"],"prefix":"10.1002","volume":"67","author":[{"given":"Jacques\u2010Fran\u00e7ois","family":"Massa","sequence":"first","affiliation":[{"name":"Department of Epileptology and Brain Rhythmology Timone Hospital  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nada","family":"El Youssef","sequence":"additional","affiliation":[{"name":"Department of Epileptology and 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