{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:37:43Z","timestamp":1783485463195,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006093","name":"Patient-Centered Outcomes Research Institute","doi-asserted-by":"publisher","award":["2015C2\u20101507\u201031187"],"award-info":[{"award-number":["2015C2\u20101507\u201031187"]}],"id":[{"id":"10.13039\/100006093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS111166"],"award-info":[{"award-number":["R01NS111166"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess long\u2010term safety of antiseizure medication (ASM) discontinuation after resolution of acute provoked neonatal seizures and prior to hospital discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Prospective, observational, comparative effectiveness cohort study of neonates with acute provoked seizures born from July 2015 to March 2018, and followed until September 2024, at nine U.S.\n                      <jats:italic>Neonatal Seizure Registry<\/jats:italic>\n                      centers with Level IV neonatal intensive care units and Level IV pediatric epilepsy programs. Duration of ASM treatment was quantified as (1) discontinuation before discharge from the neonatal seizure admission or (2) maintenance at the time of hospital discharge. Outcomes were adjusted for propensity to receive ASM at discharge. Propensity for ASM maintenance was defined among enrolled participants by a logistic regression model including seizure etiology, gestational age, therapeutic hypothermia, worst electroencephalography (EEG) background, days of EEG seizures, and discharge neurological exam (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u2009.1 in a joint model, except etiology, which was included for face validity). The primary outcome was non\u2010inferiority of cognition (Wechsler Preschool and Primary Scale of Intelligence assessed at age 5\u20136\u2009years). Secondary outcomes were non\u2010inferiority of functional development (Vineland Adaptive Behavior Scale, 3rd Edition, assessed at 3\u20138\u2009years) and post\u2010neonatal epilepsy (assessed at 1\u20138\u2009years).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 284 children with at least one follow\u2010up, outcomes were similar in the discontinued vs maintained ASM groups for full\u2010scale IQ at age 5\u2009years (adjusted difference +10 points), functional development at ages 3\u20138\u2009years (adjusted difference 0 points), and post\u2010neonatal epilepsy at ages 1\u20138\u2009years (adjusted hazard ratio .93, 95% confidence interval [CI] .48\u20131.80).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Prolonged administration of ASM for several months after resolution of acute provoked neonatal seizures may expose infants to unnecessary medications. These results provide additional evidence for safety of discontinuing ASM for most neonates soon after the resolution of acute provoked seizures\u2014a practice that is recommended in the International League Against Epilepsy (ILAE) guideline for neonatal seizure management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70192","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T04:14:32Z","timestamp":1773461672000},"page":"2836-2844","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010term safety of early discontinuation of antiseizure medication after resolution of acute provoked neonatal seizures"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3879-1966","authenticated-orcid":false,"given":"Hannah C.","family":"Glass","sequence":"first","affiliation":[{"name":"Department of Neurology and Weill Institute for Neuroscience University of California San Francisco  San Francisco California USA"},{"name":"Department of Pediatrics, UCSF Benioff Children's Hospital University of California San Francisco  San Francisco California USA"},{"name":"Department of Epidemiology &amp; Biostatistics University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1594-9812","authenticated-orcid":false,"given":"Adam L.","family":"Numis","sequence":"additional","affiliation":[{"name":"Department of Neurology and Weill Institute for Neuroscience University of California San Francisco  San Francisco California USA"},{"name":"Department of Pediatrics, UCSF Benioff Children's Hospital University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6998-7753","authenticated-orcid":false,"given":"Janet S.","family":"Soul","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston Children's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1882-5567","authenticated-orcid":false,"given":"Courtney J.","family":"Wusthoff","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California Davis  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6253-775X","authenticated-orcid":false,"given":"Monica E.","family":"Lemmon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Duke University School of Medicine  Durham North Carolina USA"},{"name":"Department of Population Health Sciences Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7670-9313","authenticated-orcid":false,"given":"Catherine J.","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"},{"name":"Kennedy Krieger Institute and Johns Hopkins Children's Center  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8496-221X","authenticated-orcid":false,"given":"Shavonne L.","family":"Massey","sequence":"additional","affiliation":[{"name":"Department of Neurology Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department of Pediatrics Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania 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