{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:27:56Z","timestamp":1790731676782,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100018439","name":"SK Life Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018439","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Cenobamate has been shown to be an effective antiseizure medication for some patients with drug\u2010resistant focal epilepsy being considered for epilepsy surgery. This retrospective single\u2010center study evaluated whether surgery was obtained within 12\u2009months for patients who received cenobamate as a treatment during the presurgical evaluation and those who did not, comparing across years before and after cenobamate approval.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients undergoing surgical evaluation for drug\u2010resistant focal epilepsy at the University of Colorado during 2018 and 2023 who had 12\u2009months of follow\u2010up data were analyzed. Comparison years were also chosen to avoid the confounding effect of the COVID\u201019 pandemic on surgical volume (2020\u20132021). This allowed for comparison times before and after cenobamate's US Food and Drug Administration approval. The primary outcome (surgery within 12\u2009months) was modeled with potential explanatory variables using multiple logistic regression. A\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value of &lt;.05 was considered significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After controlling for potentially confounding clinical and demographic variables, cenobamate use during the presurgical evaluation period was associated with .13 lower odds of surgery within 12\u2009months compared to not being prescribed this medication (95% confidence interval [CI] = .04\u2013.42,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). Being Hispanic or Latino was significantly associated with .23 lower odds of surgery within 12\u2009months compared to patients who did not report being Hispanic or Latino (95% CI = .09\u2013.61,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.003). Year of evaluation (2023 vs. 2018), education level, age, and sex did not have significant associations with undergoing surgery within 12\u2009months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Patients with drug\u2010resistant focal epilepsy undergoing evaluation for epilepsy surgery may benefit from cenobamate. In this study, patients who received cenobamate during the presurgical evaluation were less likely to undergo surgery within 12\u2009months. The delay to surgery identified among Hispanic and Latino patients suggests potential barriers to care in this patient population warranting further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70215","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T14:50:57Z","timestamp":1774536657000},"page":"3410-3419","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Delayed and deferred surgery associated with cenobamate use in people with drug\u2010resistant focal epilepsy"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0747-7210","authenticated-orcid":false,"given":"Jacob","family":"Pellinen","sequence":"first","affiliation":[{"name":"Department of Neurology University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1998-7704","authenticated-orcid":false,"given":"Stefan","family":"Sillau","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0627-702X","authenticated-orcid":false,"given":"Aimee","family":"Bui","sequence":"additional","affiliation":[{"name":"College of Osteopathic Medicine Rocky Vista University  Englewood Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Danciutiu","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9347-3776","authenticated-orcid":false,"given":"Lesley","family":"Kaye","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashvin","family":"Sood","sequence":"additional","affiliation":[{"name":"SSM Health  Fond du Lac Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1079-0677","authenticated-orcid":false,"given":"Louis","family":"Ferrari","sequence":"additional","affiliation":[{"name":"SK Life Science  Paramus New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9504-3980","authenticated-orcid":false,"given":"William E.","family":"Rosenfeld","sequence":"additional","affiliation":[{"name":"Comprehensive Epilepsy Care Center for Children and Adults  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1338-5950","authenticated-orcid":false,"given":"Christopher","family":"Elder","sequence":"additional","affiliation":[{"name":"New York University Grossman School of Medicine and New York University Langone Health  New York New York 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