{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T15:04:56Z","timestamp":1783955096761,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004504","name":"Lietuvos Mokslo Taryba","doi-asserted-by":"publisher","award":["P\u2010MIP\u201023\u2010333"],"award-info":[{"award-number":["P\u2010MIP\u201023\u2010333"]}],"id":[{"id":"10.13039\/501100004504","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Limited evidence supports the use of cognitive and psychosocial rehabilitation programs for people with epilepsy (PWE). We assessed the effects of a newly designed cognitive and psychological counseling intervention on patient\u2010reported and neuropsychological outcomes in a mixed sample of PWE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Seventy adult PWE (57.1% female, mean age\u2009=\u200935.9\u2009\u00b1\u200911.7\u2009years, 57.1% with focal epilepsy) were randomized (1:1) to either an early intervention group (EIG) or a waiting list for a late intervention group (LIG). The intervention consisted of six individual and two group counseling sessions incorporating psychoeducation, cognitive training, coping strategies, and mindfulness. Both groups were assessed at baseline and 4 and 16\u2009weeks. Primary endpoints were quality of life (Patient\u2010Weighted Quality of Life in Epilepsy 31\u2010item inventory [QOLIE\u201031\u2010P]) and delayed verbal and visual recall at 4\u2009weeks; secondary endpoints included symptoms of anxiety (Generalized Anxiety Disorder seven\u2010item scale), depression (Neurological Disorders Depression Inventory in Epilepsy), and stigma. Linear mixed models with maximum likelihood estimation were used for repeated measures analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Follow\u2010up data were available for 66 participants (94.3%) at 4\u2009weeks and 61 (87.1%) at 16\u2009weeks. The EIG showed significant improvements on the QOLIE compared with the LIG (group by time interaction\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.006), which were maintained at both follow\u2010ups. Anxiety symptoms were also significantly reduced in the EIG (group by time interaction\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.006). These effects were observed in both focal and generalized epilepsy. No significant group differences were found for delayed verbal or visual recall over time. However, greater long\u2010term forgetting on the word list task was observed in the LIG at 4\u2009weeks. No significant changes were detected for symptoms of depression or perceived stigma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>An 8\u2010week cognitive and psychosocial rehabilitation program improved quality of life and reduced anxiety in PWE, with effects sustained for up to 16\u2009weeks. Cognitive benefits were limited, with a possible transient effect on long\u2010term verbal recall. These findings support the use of rehabilitation interventions to enhance patient\u2010reported outcomes across epilepsy subtypes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70248","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T15:38:41Z","timestamp":1776267521000},"page":"3674-3685","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rehabilitation of cognition and psychosocial well\u2010being in epilepsy: Results of a randomized waiting list\u2010controlled trial"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8527-3902","authenticated-orcid":false,"given":"Kristijonas","family":"Puteikis","sequence":"first","affiliation":[{"name":"Faculty of Medicine Vilnius University  Vilnius 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