{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:46:05Z","timestamp":1793234765603,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100001454","name":"American Epilepsy Society","doi-asserted-by":"publisher","award":["1153665"],"award-info":[{"award-number":["1153665"]}],"id":[{"id":"10.13039\/100001454","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The International Classification of Cognitive Disorders in Epilepsy (IC\u2010CoDE) is a consensus\u2010based, empirically\u2010driven approach to standardize cognitive phenotyping in epilepsy research that has quickly garnered interest within the epilepsy community. However, manually generating IC\u2010CoDE phenotypes in group data is laborious and time\u2010consuming, particularly in datasets containing heterogenous cognitive measures or batteries, limiting the widespread adoption of IC\u2010CoDE phenotypes to further multicenter epilepsy research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      To remove this barrier, we developed the IC\u2010CoDE Portal (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/ic-code-portal.ccf.org\/\">https:\/\/ic\u2010code\u2010portal.ccf.org\/<\/jats:ext-link>\n                      ), an interactive and user\u2010friendly, web\u2010based platform to support the scientific community in performing IC\u2010CoDE individual level classification through web interface or bulk classification through uploading of data files. The Portal also allows the user to generate and visualize cohort summary statistics of cognitive phenotypes in their dataset, with the option of filtering the data interactively by specified demographic or clinical variables of interest. We further made the resulting IC\u2010CoDE phenotypes downloadable as a spreadsheet to foster offline analysis of cognitive data by members of the epilepsy research community.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Ascertainment of cognitive profiles is key to understanding the natural heterogeneity in the clinical presentation of the epilepsies and their comorbidities. The IC\u2010CoDE taxonomy can be applied to any comprehensive neuropsychological battery, regardless of the specific test measures and normative data used or the language and culture in which the assessment took place, making it an ideal tool to accelerate international multi\u2010center studies on cognition in epilepsy. We hope that by eliminating some of the barriers associated with cognitive phenotyping, the IC\u2010CoDE Portal will springboard large\u2010scale collaborative efforts to further our understanding of the neuropsychology of the epilepsies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70263","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T14:44:53Z","timestamp":1778165093000},"page":"4255-4264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The International Classification of Cognitive Disorders in Epilepsy (\n                    <scp>IC<\/scp>\n                    \u2010\n                    <scp>CoDE<\/scp>\n                    ) Portal: An open source resource for neuropsychological research in epilepsy"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5442-4912","authenticated-orcid":false,"given":"Robyn M.","family":"Busch","sequence":"first","affiliation":[{"name":"Epilepsy Center, Neurological Institute Cleveland Clinic  Cleveland Ohio USA"},{"name":"Department of Neurology, Neurological Institute Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2591-432X","authenticated-orcid":false,"given":"Tobias","family":"Br\u00fcnger","sequence":"additional","affiliation":[{"name":"Department of Neurology The University of Texas Health Science Center  Houston Texas USA"},{"name":"Center for Neurogenetics The University of Texas Health Science Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6482-4795","authenticated-orcid":false,"given":"Kayela","family":"Arrotta","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Neurological Institute Cleveland Clinic  Cleveland Ohio USA"},{"name":"Department of Neurology, Neurological Institute Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3577-2257","authenticated-orcid":false,"given":"Lisa","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Neurological Institute Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5188-9415","authenticated-orcid":false,"given":"Julie K.","family":"Janecek","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4861-7913","authenticated-orcid":false,"given":"Sara J.","family":"Swanson","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0625-6990","authenticated-orcid":false,"given":"Anny","family":"Reyes","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Neurological Institute Cleveland Clinic  Cleveland Ohio USA"},{"name":"Department of Neurology, Neurological Institute Cleveland Clinic  Cleveland Ohio USA"},{"name":"Department of Radiation Medicine and Applied Sciences University of California San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1509-1434","authenticated-orcid":false,"given":"Brook","family":"Hurd","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Neurological Institute Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8369-5363","authenticated-orcid":false,"given":"Mark","family":"St. John","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Neurological Institute Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0721-5640","authenticated-orcid":false,"given":"Carrie R.","family":"McDonald","sequence":"additional","affiliation":[{"name":"Department of Radiation Medicine and Applied Sciences University of California San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0133-4427","authenticated-orcid":false,"given":"Bruce P.","family":"Hermann","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5173-9636","authenticated-orcid":false,"given":"Dennis","family":"Lal","sequence":"additional","affiliation":[{"name":"Department of Neurology The University of Texas Health Science Center  Houston Texas USA"},{"name":"Center for Neurogenetics The University of Texas Health Science Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2014.06.002"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2010.09.001"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acq024"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12478"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102341"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2009.05.012"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007370"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16283"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2021.107841"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000792"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.18043"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2023.109471"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17795"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207266"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17501"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2026.111001"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26893"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2025.110606"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2025.110607"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12991"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/15357597231211446"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/15357597231159467"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2026.110938"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epi.70263","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/epi.70263","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epi.70263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T10:05:43Z","timestamp":1787997943000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/epi.70263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,7]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/epi.70263"],"URL":"https:\/\/doi.org\/10.1002\/epi.70263","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,7]]},"assertion":[{"value":"2025-12-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}