{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:58:56Z","timestamp":1790675936254,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the impact of the operated brain region and clinical\u2013surgical variables on intellectual performance in children and adolescents undergoing neurosurgery for pharmacoresistant epilepsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010one participants were classified according to surgical site: temporal lobe (TL;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923), frontal lobe (FL;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099), posterior cortex (PC;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099), and hemispherotomy (H;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910). Neuropsychological assessment was performed using age\u2010appropriate versions of the Wechsler Intelligence Scales (Wechsler Intelligence Scale for Children\/Wechsler Adult Intelligence Scale [WISC\/WAIS]). Bayesian linear mixed models compared intelligence quotients and scale indices across three time points: preoperative (T0), 6\u2010month postoperative (T1), and 24\u2010month postoperative (T2). For each outcome, two models were fitted: a simple model and a multiple model adjusted for seizure frequency and epilepsy duration. Estimates were derived from posterior distributions with 95% credibility intervals. Analyses were conducted in R using MCMC sampling, with convergence assessed by trace plots and the Gelman\u2013Rubin diagnostic. A change of \u226510 points was considered a clinically relevant improvement, whereas a decrease of \u22655 points indicated a relevant decline in longitudinal within\u2010group comparisons. Results reflect group\u2010level trajectories rather than individual outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At T1, the H group showed declines in Full\u2010Scale Intelligence Quotient (FSIQ), Verbal Comprehension Index (VCI), Perceptual Organization Index (POI), Working Memory Index (WMI), and Processing Speed Index (PSI). At T2, the FSIQ, POI, and WMI returned to near baseline, whereas VCI and PSI remained reduced. The TL group showed declines in VCI, WMI, and PSI at T1, with a persistent reduction in VCI at T2. FL and PC groups maintained intelligence indices close to baseline at both postoperative assessments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Epilepsy surgery preserved intellectual functioning, particularly in FL and PC procedures. However, persistent VCI decline in H and TL groups suggests effects on verbal abilities associated with temporal lobe involvement. Sustained PSI reduction after hemispherotomy may indicate decreased cognitive efficiency and slower information processing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70275","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T16:16:26Z","timestamp":1784996186000},"page":"4954-4967","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal Bayesian analysis of lobe\u2010specific cognitive outcomes after pediatric epilepsy surgery"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8993-1310","authenticated-orcid":false,"given":"Geisa","family":"de Angelis","sequence":"first","affiliation":[{"name":"Nuclear Medicine and PET\/CT Section, Department of Medical Imaging, Hematology and Clinical Oncology, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"},{"name":"Epilepsy Surgery Center (CIREP), Department of Neurosciences and Behavioral Sciences, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4016-5806","authenticated-orcid":false,"given":"Lucas Emmanuel","family":"Lopes\u2010Santos","sequence":"additional","affiliation":[{"name":"Nuclear Medicine and PET\/CT Section, Department of Medical Imaging, Hematology and Clinical Oncology, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"},{"name":"Epilepsy Surgery Center (CIREP), Department of Neurosciences and Behavioral Sciences, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1019-3654","authenticated-orcid":false,"given":"Davi Casale","family":"Aragon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo (FMRP\/USP)  Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7756-8882","authenticated-orcid":false,"given":"Tonicarlo","family":"Rodrigues Velasco","sequence":"additional","affiliation":[{"name":"Epilepsy Surgery Center (CIREP), Department of Neurosciences and Behavioral Sciences, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9157-790X","authenticated-orcid":false,"given":"Ursula Thom\u00e9","family":"Costa","sequence":"additional","affiliation":[{"name":"Epilepsy Surgery Center (CIREP), Department of Neurosciences and Behavioral Sciences, Ribeir\u00e3o Preto Medical School University of 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Rubens","family":"Machado","sequence":"additional","affiliation":[{"name":"Department of Surgery and Anatomy, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1884-7264","authenticated-orcid":false,"given":"Ana Paula Andrade","family":"Hamad","sequence":"additional","affiliation":[{"name":"Epilepsy Surgery Center (CIREP), Department of Neurosciences and Behavioral Sciences, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5502-4734","authenticated-orcid":false,"given":"Antonio Carlos","family":"Santos","sequence":"additional","affiliation":[{"name":"Nuclear Medicine and PET\/CT Section, Department of Medical Imaging, Hematology and Clinical Oncology, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo 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