{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T10:19:43Z","timestamp":1787998783057,"version":"build-2784847793"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100022434","name":"Walloon excellence in life sciences and biotechnology","doi-asserted-by":"publisher","award":["X.2001.22"],"award-info":[{"award-number":["X.2001.22"]}],"id":[{"id":"10.13039\/501100022434","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Cardioventilatory failure is the leading mechanism proposed to underlie sudden unexpected death in epilepsy (SUDEP), which occurs predominantly at night in patients with generalized tonic\u2013clonic seizures. Interictal hypercapnic cardioventilatory responses are suggested to be involved, as they are ablated in chronically epileptic kainic acid (KA) rats, a temporal lobe epilepsy model with focal to bilateral tonic\u2013clonic seizures. However, how this impairment emerges during epileptogenesis and whether it is influenced by day\/night period remain unclear. Here, we aimed to investigate the progress of hypercapnic cardioventilatory responses through the epileptogenesis of KA rats and whether it is affected by day or night.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Ventilatory or breathing frequency (f\n                      <jats:sub>B<\/jats:sub>\n                      ) and heart rate (HR) were measured before, during, and after a 1\u2010h exposure to acute hypercapnia (10% CO\n                      <jats:sub>2<\/jats:sub>\n                      ) using photoplethysmography in KA and healthy rats. Measurements were performed monthly for 6\u2009months, with additional nocturnal hypercapnia recordings at month 6 to assess day\/night modulation. To control for repeated CO\n                      <jats:sub>2<\/jats:sub>\n                      exposure, an independent cohort of age\u2010matched KA and healthy rats underwent a single hypercapnia exposure at month 6.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In healthy rats, cardioventilatory responses to hypercapnia remained stable over time, with increased f\n                      <jats:sub>B<\/jats:sub>\n                      and reduced HR. Conversely, KA rats displayed an abrupt blunting of the f\n                      <jats:sub>B<\/jats:sub>\n                      response at month 4, followed by blunting of the HR response at month 6. Correlation analyses revealed a loss of correlation between f\n                      <jats:sub>B<\/jats:sub>\n                      and HR following KA injection, which reemerged when the cardioventilatory response to CO\n                      <jats:sub>2<\/jats:sub>\n                      was fully ablated. No association was observed between seizure severity and cardioventilatory impairment. KA rats displayed similar deficits regardless of CO\n                      <jats:sub>2<\/jats:sub>\n                      exposure frequency, and no day\u2013night differences were detected in either group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>These findings indicate that cardioventilatory responses are decreased during epileptogenesis in the KA model, suggesting their potential utility for evaluating SUDEP risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70284","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T15:11:13Z","timestamp":1778512273000},"page":"4334-4347","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of epileptogenesis on hypercapnic cardioventilatory response in kainic acid rats"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2062-104X","authenticated-orcid":false,"given":"Auriane","family":"Apaire","sequence":"first","affiliation":[{"name":"Clinical Neuroscience, Institute of Neuroscience Universit\u00e9 Catholique de Louvain  Brussels Belgium"},{"name":"Walloon Excellence in Life Sciences and Biotechnology Department Walloon Excellence in Life Research Institute  Wavre Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1576-9142","authenticated-orcid":false,"given":"Elise","family":"Collard","sequence":"additional","affiliation":[{"name":"Clinical Neuroscience, Institute of Neuroscience Universit\u00e9 Catholique de Louvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2864-9591","authenticated-orcid":false,"given":"Abigail","family":"Niyibizi","sequence":"additional","affiliation":[{"name":"Clinical Neuroscience, Institute of Neuroscience Universit\u00e9 Catholique de Louvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4712-8792","authenticated-orcid":false,"given":"Natasha N.","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Biomedical Sciences University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3100-187X","authenticated-orcid":false,"given":"Enrique","family":"Germany Morrison","sequence":"additional","affiliation":[{"name":"Clinical Neuroscience, Institute of Neuroscience Universit\u00e9 Catholique de Louvain  Brussels Belgium"},{"name":"Walloon Excellence in Life Sciences and Biotechnology Department Walloon Excellence in Life Research Institute  Wavre Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1155-6701","authenticated-orcid":false,"given":"Javier","family":"Chavez Cerda","sequence":"additional","affiliation":[{"name":"Systems &amp; Cognitive Neuroscience, Institute of Neuroscience Universit\u00e9 Catholique de Louvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5584-197X","authenticated-orcid":false,"given":"Ayse S.","family":"Dereli","sequence":"additional","affiliation":[{"name":"Clinical Neuroscience, Institute of Neuroscience Universit\u00e9 Catholique de Louvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2440-0194","authenticated-orcid":false,"given":"Riem","family":"El Tahry","sequence":"additional","affiliation":[{"name":"Clinical Neuroscience, Institute of Neuroscience Universit\u00e9 Catholique de Louvain  Brussels Belgium"},{"name":"Walloon Excellence in Life Sciences and Biotechnology Department Walloon Excellence in Life Research Institute  Wavre Belgium"},{"name":"Department of Neurology, Center for Refractory Epilepsy Cliniques Universitaires Saint\u2010Luc  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70214-X"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12666"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001260"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1010481"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12576-018-0602-z"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI94999"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0450-23.2023"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi.70123"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2004.11.009"},{"issue":"1","key":"e_1_2_12_11_1","first-page":"166","article-title":"Effects of hypercapnia, hypoxia, and rebreathing on heart rate response during apnea","volume":"54","author":"Lin YC","year":"1983","journal-title":"J Appl Physiol Respir Environ Exerc Physiol"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1971.sp009525"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207921"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.618841"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004094"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03360.x"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.64.3.349"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2010.07.006"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.01079"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.00683.x"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(97)00056-X"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1427308"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12868-019-0490-z"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1999.tb00849.x"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(72)90177-0"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21082706"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.08.016"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.83654"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2020.05.002"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2023.1288600"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14660"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51382"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000820"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-014-0263-9"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1972.tb04403.x"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.132415"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt117"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6773(75)91717-4"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43834-7"},{"issue":"5","key":"e_1_2_12_40_1","first-page":"758","article-title":"Hypercapnic ventilatory response in sleeping adults","volume":"126","author":"Douglas NJ","year":"1982","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00855.2001"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-91534-2.00007-2"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1997.tb01077.x"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535759719874787"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(92)90184-X"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2013-000014"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2022.901334"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0299047"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2024.109966"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02518.x"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epi.70284","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/epi.70284","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epi.70284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T10:05:40Z","timestamp":1787997940000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/epi.70284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,11]]},"references-count":49,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/epi.70284"],"URL":"https:\/\/doi.org\/10.1002\/epi.70284","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,11]]},"assertion":[{"value":"2026-02-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}