{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T10:19:45Z","timestamp":1787998785461,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["2U01\u2010NS038455"],"award-info":[{"award-number":["2U01\u2010NS038455"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["K23NS135134"],"award-info":[{"award-number":["K23NS135134"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U01\u2010NS038455"],"award-info":[{"award-number":["U01\u2010NS038455"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U01\u2010NS050659"],"award-info":[{"award-number":["U01\u2010NS050659"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01 HD105305"],"award-info":[{"award-number":["R01 HD105305"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study was undertaken to evaluate whether seizure freedom in pregnancy predicts seizure freedom in the postpartum period in women with epilepsy (WWE). Prior studies have shown that seizure freedom prior to conception strongly predicts seizure freedom during pregnancy. The postpartum period is considered especially vulnerable to recurrent seizures given rapid hormonal changes, shifting antiseizure medication pharmacokinetics, and disrupted sleep. There is a lack of sufficient data on whether seizure freedom during pregnancy predicts postpartum outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Pregnant WWE (aged 14\u201345\u2009years) were enrolled at &lt;20\u2009weeks gestation in the prospective Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs study. Participants completed electronic daily seizure and medication diaries with study visits each trimester, and at 6\u201312\u2009weeks and 6 and 9\u2009months postpartum. Participants also reported retrospective seizure frequency for the 9\u2009months preconception. We used logistic regression to assess whether seizure freedom during pregnancy predicted seizure freedom postpartum, with additional analyses by seizure types. In participants with seizures during pregnancy, we evaluated median percent change in seizure frequency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This analysis included 331 pregnant WWE. Overall, 60.7% were seizure\u2010free during pregnancy and 61.0% postpartum. Seizure freedom during pregnancy strongly predicted seizure freedom postpartum (odds ratio [OR] =\u20096.78, 95% confidence interval [CI] =\u20094.15\u201311.1,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001), with a predictive value of 78% (95% CI\u2009=\u200972%\u201384%). Retrospectively reported preconception seizure freedom was also independently associated with postpartum seizure freedom (OR\u2009=\u20095.84, 95% CI\u2009=\u20093.57\u20139.58,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001). Long\u2010term seizure freedom during pregnancy and preconception was associated with 85% postpartum seizure freedom, whereas long\u2010term presence of seizures was associated with only 36% postpartum seizure freedom. There were no significant differences by seizure type. Among participants with seizures during pregnancy, median postpartum seizure frequency declined by 77% (interquartile range = seizure\u2010free to 31% reduced).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Our data demonstrated that seizure freedom during pregnancy was a robust predictor of seizure freedom during the postpartum period. These data can be used to counsel patients about seizure risk in the postpartum period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70288","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T09:59:33Z","timestamp":1779271173000},"page":"4109-4120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predicting seizure freedom in the postpartum period: Findings from the Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs study"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2039-9846","authenticated-orcid":false,"given":"Emma C.","family":"Osterhaus","sequence":"first","affiliation":[{"name":"Department of Neurology University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5546-5951","authenticated-orcid":false,"given":"Wesley T.","family":"Kerr","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"},{"name":"Department of Psychiatry University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Biomedical Informatics University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7471-882X","authenticated-orcid":false,"given":"Kimford J.","family":"Meador","sequence":"additional","affiliation":[{"name":"Department of Neurology &amp; Neurological Sciences Stanford University School of Medicine  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2242-8027","authenticated-orcid":false,"given":"Jacqueline A.","family":"French","sequence":"additional","affiliation":[{"name":"Comprehensive Epilepsy Center New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3969-4906","authenticated-orcid":false,"given":"Angela K.","family":"Birnbaum","sequence":"additional","affiliation":[{"name":"University of Minnesota College of Pharmacy  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5216-2018","authenticated-orcid":false,"given":"P. Emanuela","family":"Voinescu","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital\u2013Mass General Brigham Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3062-8360","authenticated-orcid":false,"given":"Elizabeth","family":"Gerard","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0568-2795","authenticated-orcid":false,"given":"Page B.","family":"Pennell","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003509"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181a6b2f8"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2015.02.012"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1997.tb01197.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2015.11.009"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000214483"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.5487"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2008663"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000289511.20864.2a"},{"key":"e_1_2_11_11_1","doi-asserted-by":"crossref","unstructured":"LiD PennellPB KerrWT PackAM FrenchJ GerardE et\u00a0al.Antiseizure medication dosing strategy during pregnancy and early postpartum in women with epilepsy in MONEAD. Poster presentation presented at: annual conference of the international league against epilepsy.2025Lisbon Portugal.","DOI":"10.1212\/WNL.0000000000214483"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2024.2375"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.18338"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.519"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17471"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.18109"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17621"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi.70080"},{"key":"e_1_2_11_19_1","unstructured":"Explore the Research \u2010 Epilepsy & Pregnancy Medical Consortium. [cited 2026 Jan 21]. 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