{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T10:19:29Z","timestamp":1787998769173,"version":"build-2784847793"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Hippocampal sclerosis (HS) is the most common histopathological abnormality in adults with drug\u2010resistant mesial temporal lobe epilepsy (MTLE) who are candidates for surgery. In 2013, the International League Against Epilepsy (ILAE) Task Force subdivided HS into three types: HS\u2010ILAE type 1 (severe neuronal loss and gliosis predominantly in CA1 and CA4), HS\u2010ILAE type 2 (CA1\u2010predominant), and HS\u2010ILAE type 3 (CA4\u2010predominant). The aim of this study was to assess the association between HS\u2010ILAE types and cognitive profiles of MTLE\u2010HS patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 302 patients were retrospectively included, comprised of 253 MTLE\u2010HS patients with a postoperative ILAE classification of HS as follows: 194 HS\u2010ILAE type 1, 57 HS\u2010ILAE type 2, and two HS\u2010ILAE type 3; and 49 MTLE patients without HS. Demographic variables, clinical characteristics, postoperative outcome, and cognitive performance were compared between patients with HS\u2010ILAE type 1, with HS\u2010ILAE type 2, and without HS, who served as internal controls. Height cognitive domains were examined: general cognition, verbal and nonverbal episodic memory, language, executive functions, short\u2010term and working memory, perceptual\u2013motor speed, and visuoconstructive abilities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The pattern of hippocampal neuronal loss was not associated with age at epilepsy onset, the presence of specific initial precipitating events, other clinical characteristics, or postoperative outcome. Patients with HS\u2010ILAE type 1 demonstrated significantly poorer performance in visuoconstructive and language tasks compared with those with HS\u2010ILAE type 2 or patients without HS. No significant differences were observed between groups in verbal and nonverbal episodic memory, short\u2010term memory, executive functions, or perceptual\u2013motor speed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>HS\u2010ILAE subtype has a modest yet differential impact on patient performance, with HS\u2010ILAE type 1 patients demonstrating overall poorer outcomes across two cognitive domains: language and visuoconstructive function. These findings suggest that cognitive impairment in MTLE\u2010HS likely reflects a complex interplay among multiple pathological processes, including, in part, neuronal loss within specific hippocampal subfields. More targeted neuropsychological assessments focusing on the functional integrity of distinct hippocampal subregions are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70295","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T10:02:56Z","timestamp":1780308176000},"page":"4265-4276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Influence of histopathologic type of hippocampal sclerosis on neuropsychological profile"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4754-0998","authenticated-orcid":false,"given":"Nhan","family":"Le Thanh","sequence":"first","affiliation":[{"name":"Rehabilitation Unit Assistance publique\u2010H\u00f4pitaux de Paris, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Houot","sequence":"additional","affiliation":[{"name":"Center of Excellence of Neurodegenerative Disease, Assistance publique\u2010H\u00f4pitaux de Paris, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"},{"name":"Institute of Memory and Alzheimer's Disease, Department of Neurology, Assistance publique\u2010H\u00f4pitaux de Paris, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"},{"name":"Clinical Investigation Center Paris Brain Institute, Institut du Cerveau, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Mere","sequence":"additional","affiliation":[{"name":"Assistance publique\u2010H\u00f4pitaux de Paris, Epileptology Unit, Reference Center for Rare Epilepsies, European Reference Network EpiCARE, Department of Neurology Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Denos","sequence":"additional","affiliation":[{"name":"Rehabilitation Unit Assistance publique\u2010H\u00f4pitaux de Paris, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Samson","sequence":"additional","affiliation":[{"name":"Assistance publique\u2010H\u00f4pitaux de Paris, Epileptology Unit, Reference Center for Rare Epilepsies, European Reference Network EpiCARE, Department of Neurology Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"},{"name":"Psychologie: Interactions, Temps, Emotions, Cognition Universit\u00e9 de Lille, Unit\u00e9 Labellis\u00e9e de Recherche 4072  Lille France"},{"name":"Universit\u00e9 Paris Cit\u00e9 Institut Pasteur, Assistance publique\u2010H\u00f4pitaux de Paris, Inserm, Centre national de la recherche scientifique, Fondation Pour l'Audition, Institut de l'Audition, Institut hospitalo\u2010universitaire reConnect  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9182-5846","authenticated-orcid":false,"given":"Bertrand","family":"Mathon","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Assistance publique\u2010H\u00f4pitaux de Paris, Sorbonne Universit\u00e9, La Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"},{"name":"Universit\u00e9 Sorbonne  Paris France"},{"name":"Paris Brain Institute, Centre national de la recherche scientifique, Inserm  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0077-8114","authenticated-orcid":false,"given":"Vincent","family":"Navarro","sequence":"additional","affiliation":[{"name":"Assistance publique\u2010H\u00f4pitaux de Paris, Epileptology Unit, Reference Center for Rare Epilepsies, European Reference Network EpiCARE, Department of Neurology Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"},{"name":"Universit\u00e9 Sorbonne  Paris France"},{"name":"Paris Brain Institute, Centre national de la recherche scientifique, Inserm  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Bielle","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Sorbonne  Paris France"},{"name":"Department of Neuropathology Assistance publique\u2010H\u00f4pitaux de Paris, Sorbonne Universit\u00e9, La Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2080-8253","authenticated-orcid":false,"given":"Sophie","family":"Dupont","sequence":"additional","affiliation":[{"name":"Rehabilitation Unit Assistance publique\u2010H\u00f4pitaux de Paris, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"},{"name":"Assistance publique\u2010H\u00f4pitaux de Paris, Epileptology Unit, Reference Center for Rare Epilepsies, European Reference Network EpiCARE, Department of Neurology Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"},{"name":"Universit\u00e9 Sorbonne  Paris France"},{"name":"Paris Brain Institute, Centre national de la recherche scientifique, Inserm  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12220"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-017-8441-z"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-006-0187-0"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2003.32701.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02681.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2020.107380"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2014.10.006"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12596"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17757"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A8214"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2016.08.012"},{"issue":"3","key":"e_1_2_12_13_1","first-page":"404","article-title":"Relation between ILAE hippocampal sclerosis classification and clinical findings in temporal lobe epilepsy","volume":"31","author":"Hasimoglu O","year":"2021","journal-title":"Turk Neurosurg"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13277"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2017.02.013"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12514"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17979"},{"key":"e_1_2_12_18_1","article-title":"Activating Ras\u2010MAPK pathway variants drive hippocampal clonal competition in human epilepsy","volume":"27","author":"Khoshkhoo S","year":"2026","journal-title":"bioRxiv"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.049107"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-10307-6"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(91)90157-H"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2016.07.009"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(00)00104-4"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1603312113"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20733"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2020.10.031"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0074\u20107742(08)60352\u20109"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1063(2000)10:4<491::AID-HIPO16>3.0.CO;2-0"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-022-00738-2"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3008"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291718003458"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu100"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14036"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22238"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.045781.117"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22561"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2013.00074"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2312752120"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2024.107405"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.5698\/1535-7597.18.5.298"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epi.70295","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/epi.70295","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epi.70295","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T10:04:51Z","timestamp":1787997891000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/epi.70295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,1]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/epi.70295"],"URL":"https:\/\/doi.org\/10.1002\/epi.70295","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,1]]},"assertion":[{"value":"2026-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}