{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T10:19:46Z","timestamp":1787998786138,"version":"build-2784847793"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["D43 TW001140"],"award-info":[{"award-number":["D43 TW001140"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The objective of the study was to assess the frequency of interictal epileptiform discharges (IEDs) in calcified neurocysticercosis (NCC) and its relationship with calcification burden. Forty\u2010nine patients with calcified NCC (low\u2010burden, 1\u20132 calcifications,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200924; high\u2010burden, \u226515 calcifications,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200925) and seizure history underwent prolonged (8\u2010h) electroencephalography (EEG), interpreted by epileptologists who were blinded to patient history and calcification category. Clinical seizure outcomes were also assessed. We found that IEDs occurred in 7 of 49 participants (14.3%), with no difference between low\u2010burden (12.5%) and high\u2010burden (16.0%) groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20091.000). All IEDs (spikes and\/or sharp waves) in the high\u2010burden group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20094) were high\u2010voltage (100\u2013150\u2009\u03bcV), whereas those in the low\u2010burden group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20093) were low or medium voltage (20\u201370\u2009\u03bcV). Among the participants who had IEDs, 5 (71.4%) had seizures in the last year, compared with 14 (33.3%) in the group without IEDs detected (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.093). Among 19 participants with seizures in the last year, 5 were identified as having drug\u2010resistant epilepsy (DRE). All five cases of DRE occurred in individuals with 15 or more calcifications (5\/25, 20%, vs 0\/24,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.023). We conclude that IEDs occur frequently in individuals with calcified NCC. Although calcification burden itself was not associated with the presence of IEDs, drug\u2010resistant cases and high\u2010voltage IEDs were concentrated in the high\u2010burden group, supporting the role of calcified parasites as epileptogenic foci.\n                  <\/jats:p>","DOI":"10.1002\/epi.70314","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T13:00:51Z","timestamp":1780664451000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interictal epileptiform discharges in calcified neurocysticercosis\u2013associated epilepsy: An exploratory study"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6101-1286","authenticated-orcid":false,"given":"Sofia S.","family":"Sanchez\u2010Boluarte","sequence":"first","affiliation":[{"name":"Epilepsy Department Instituto Nacional de Ciencias Neurol\u00f3gicas  Lima Peru"},{"name":"Neurosciences, Epidemiology and Global Health Research Group Universidad Cesar Vallejo  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6598-1780","authenticated-orcid":false,"given":"Liza N.","family":"Nu\u00f1ez Del Prado","sequence":"additional","affiliation":[{"name":"Epilepsy Department Instituto Nacional de Ciencias Neurol\u00f3gicas  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2044-6183","authenticated-orcid":false,"given":"Denisse","family":"Chacon","sequence":"additional","affiliation":[{"name":"Epilepsy Department Instituto Nacional de Ciencias Neurol\u00f3gicas  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8886-3358","authenticated-orcid":false,"given":"Marlene","family":"Huamani","sequence":"additional","affiliation":[{"name":"Epilepsy Department Instituto Nacional de Ciencias Neurol\u00f3gicas  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7857-9792","authenticated-orcid":false,"given":"Betsab\u00e9","family":"Callupe\u2010Luna","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universidad Peruana Cayetano Heredia  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7692-5030","authenticated-orcid":false,"given":"Javier A.","family":"Bustos","sequence":"additional","affiliation":[{"name":"Cysticercosis Unit Instituto Nacional de Ciencias Neurol\u00f3gicas  Lima Peru"},{"name":"Center for Global Health Universidad Peruana Cayetano Heredia  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4536-3791","authenticated-orcid":false,"given":"William O.","family":"Tatum","sequence":"additional","affiliation":[{"name":"Center for Global Health Universidad Peruana Cayetano Heredia  Lima Peru"},{"name":"Department of Neurology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4633-6269","authenticated-orcid":false,"given":"Hector H.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Cysticercosis Unit Instituto Nacional de Ciencias Neurol\u00f3gicas  Lima Peru"},{"name":"Center for Global Health Universidad Peruana Cayetano Heredia  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Cysticercosis Working Group in Peru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,5]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002692"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix027"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2015.07.001"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.14581\/jer.21018"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2021.1276"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens13010026"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.11.045"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.18338"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2009.02397.x"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16977"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009439"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0000000000000806"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2018.06.011"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(08)70243\u20106"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12849"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004\u2010282X2006000600003"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.21\u20100392"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epi.70314","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/epi.70314","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epi.70314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T10:05:22Z","timestamp":1787997922000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/epi.70314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,5]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/epi.70314"],"URL":"https:\/\/doi.org\/10.1002\/epi.70314","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,5]]},"assertion":[{"value":"2026-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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