{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:57:36Z","timestamp":1790675856133,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH\u2010DIR ZIA NS009431\u201005"],"award-info":[{"award-number":["NIH\u2010DIR ZIA NS009431\u201005"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study was undertaken to reliably estimate individual\u2010specific resting\u2010state cortical networks and determine whether language network topography can predict task\u2010based language dominance in drug\u2010resistant epilepsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We utilized a multisession hierarchical Bayesian model (MS\u2010HBM) trained on drug\u2010resistant epilepsy patients to map high\u2010quality individual\u2010specific cortical networks in this population (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200965) with only 6\u201324\u2009min of resting\u2010state functional magnetic resonance imaging (fMRI). We compared the quality of networks to MS\u2010HBM models trained on healthy participants from the human connectome project (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940) and tested the generalizability of the model in an independent cohort of drug\u2010resistant epilepsy participants (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200926). Resting\u2010state language network topography was then used to predict task\u2010based language dominance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010one participants with drug\u2010resistant epilepsy (National Institutes of Health,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200965; University of Iowa,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200926) were included: 61 (67.0%) temporal lobe epilepsy, 29 (31.9%) extratemporal lobe epilepsy, and one (1.1%) undetermined seizure onset zone. The mean age was 33.0\u2009\u00b1\u200911.4\u2009years, and 50 (54.9%) were male. There were 40 healthy participants with a mean age of 29.0\u2009\u00b1\u20094.0\u2009years, and 16 (40.0%) were male. MS\u2010HBM trained on drug\u2010resistant epilepsy estimated individual\u2010specific networks that more accurately capture cortical functional organization than group\u2010average networks or MS\u2010HBM trained on healthy participants. The trained MS\u2010HBM model generalized to an independent cohort of drug\u2010resistant epilepsy participants with concurrent intracranial electrical stimulation and fMRI. Critically, cortical evoked fMRI activity aligned more closely with individual\u2010specific networks than with group\u2010average networks. Furthermore, individual\u2010specific language network topography significantly predicted task\u2010based language dominance, achieving high accuracy for left (area under the curve [AUC]\u2009=\u2009.82), bilateral (AUC\u2009=\u2009.72), and right (AUC\u2009=\u2009.83) dominance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>These results demonstrate that MS\u2010HBM captures functionally meaningful network reorganization in drug\u2010resistant epilepsy and enables accurate, individual\u2010level prediction of language lateralization, with direct implications for presurgical functional mapping.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70323","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T14:12:12Z","timestamp":1780927932000},"page":"4649-4661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Individual\u2010specific resting\u2010state networks predict language dominance in drug\u2010resistant epilepsy"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6866-9531","authenticated-orcid":false,"given":"Mervyn Jun Rui","family":"Lim","sequence":"first","affiliation":[{"name":"Computational Brain Imaging Group, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"National Institute of Neurological Disorders and Stroke National Institutes of Health  Bethesda Maryland USA"},{"name":"Division of Neurosurgery, Department of Surgery National University Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6352-9150","authenticated-orcid":false,"given":"Shaoshi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Computational Brain Imaging Group, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5991-0969","authenticated-orcid":false,"given":"Shreya","family":"Pande","sequence":"additional","affiliation":[{"name":"Computational Brain Imaging Group, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7907-8594","authenticated-orcid":false,"given":"Aihuiping","family":"Xue","sequence":"additional","affiliation":[{"name":"Computational Brain Imaging Group, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7842-0329","authenticated-orcid":false,"given":"Ru","family":"Kong","sequence":"additional","affiliation":[{"name":"Computational Brain Imaging Group, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8575-3578","authenticated-orcid":false,"given":"Kareem","family":"Zaghloul","sequence":"additional","affiliation":[{"name":"National Institute of Neurological Disorders and Stroke National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7587-5085","authenticated-orcid":false,"given":"Sara","family":"Inati","sequence":"additional","affiliation":[{"name":"National Institute of Neurological Disorders and Stroke National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0119-3276","authenticated-orcid":false,"given":"B. T. Thomas","family":"Yeo","sequence":"additional","affiliation":[{"name":"Computational Brain Imaging Group, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199407000-00008"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.4.978"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000208087"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003532"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01683.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000289650.48830.1a"},{"key":"e_1_2_12_8_1","article-title":"Clinical applications of resting state functional connectivity","volume":"4","author":"Fox MD","year":"2010","journal-title":"Front Syst Neurosci"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22628"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A7110"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3171\/2020.8.PEDS20517"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25003"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20625"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-57392-7"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03464.x"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-65042-1"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00308.2023"},{"issue":"1","key":"e_1_2_12_18_1","first-page":"386","article-title":"Individual variability of the system\u2010level Organization of the Human Brain","volume":"27","author":"Gordon EM","year":"2017","journal-title":"Cereb Cortex"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.07.011"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.06.037"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00062-4"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07805-2"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70144-3"},{"key":"e_1_2_12_24_1","unstructured":"KongR XueA OoiLQR AsplundC TanXW GohSE et\u00a0al.Network\u2010based near\u2010scalp personalized Brain stimulation targets.2025bioRxiv 2025.05.15.654391."},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3171\/2018.5.JNS181057"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.06.038"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhy123"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-020-00595-y"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2015.31"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00338.2011"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.12.106"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhu239"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhx179"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2021.105401"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2016.12.014"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3423"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0905-19.2020"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114606"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00411"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25037"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq291"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008525"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13510"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12350"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2317458121"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24899"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.70250"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.1060814"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad125"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2019.106858"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000209816"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.191460"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25547"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2016.0479"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.26691"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.3171\/2020.1.PEDS19695"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epi.70323","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/epi.70323","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epi.70323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:18:05Z","timestamp":1790673485000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/epi.70323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,8]]},"references-count":55,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/epi.70323"],"URL":"https:\/\/doi.org\/10.1002\/epi.70323","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,8]]},"assertion":[{"value":"2026-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}