{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:58:10Z","timestamp":1790675890306,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["F31 NS135908"],"award-info":[{"award-number":["F31 NS135908"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R00 NS097618"],"award-info":[{"award-number":["R00 NS097618"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS075270"],"award-info":[{"award-number":["R01 NS075270"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS108445"],"award-info":[{"award-number":["R01 NS108445"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS110130"],"award-info":[{"award-number":["R01 NS110130"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Epileptogenic zone (EZ) localization is crucial for surgical treatment of patients with medication\u2010resistant epilepsy. Although simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) can detect interictal discharges for EZ localization, clinical adoption is limited by the need for specialized equipment and expertise. Prior EEG\u2010fMRI work has shown that interictal discharges produce fMRI activation in the EZ and deactivation in the default mode network. Here we use dynamic functional connectivity (dFC) to detect these opposing activations and localize potential interictal activity using fMRI without simultaneous EEG in a cohort composed primarily of temporal lobe epilepsy (TLE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We quantified dFC with the edge timeseries approach and present examples of negative dynamic functional connectivity peaks following interictal discharges in two patients with TLE who received simultaneous EEG\u2010fMRI. We defined the rate of these peaks as the \u201cdFC peak index,\u201d hypothesizing it to be elevated in epileptic tissue. We assessed this hypothesis in 62 medication\u2010resistant patients with focal epilepsy who underwent fMRI\n                      <jats:italic>without<\/jats:italic>\n                      simultaneous EEG (49 unilateral temporal, 11 bilateral temporal, 1 frontal, and 1 parietal). We Z\u2010scored dFC peak index in each patient to healthy controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009109) to identify regions with abnormally high values and tested whether these aligned with patients' EZs or correlated with clinical parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The dFC peak index was elevated in epileptic medial temporal structures in patients with TLE (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>FWE<\/jats:sub>\n                      \u2009&lt;.05). Resection of regions with higher values correlated with better seizure outcomes after surgery (area under the curve [AUC]\u2009=\u2009.80,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.0002), even in patients without hippocampal lesions on MRI (AUC\u2009=\u2009.79,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>This study presents the dFC peak index, which aims to detect interictal epileptic activity using fMRI without simultaneous EEG. Our results indicate that this measure is elevated in epileptic tissue in TLE, suggesting that it could provide unique information to guide epilepsy surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70335","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T13:09:36Z","timestamp":1781183376000},"page":"4702-4716","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The dynamic functional connectivity peak index: Detection of interictal epileptic activity with\n                    <scp>fMRI<\/scp>"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1508-5871","authenticated-orcid":false,"given":"Lucas E.","family":"Sainburg","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Vanderbilt University  Nashville Tennessee USA"},{"name":"Vanderbilt University Institute of Imaging Science Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Roche","sequence":"additional","affiliation":[{"name":"Vanderbilt University Institute of Imaging Science Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghassan S.","family":"Makhoul","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Vanderbilt University  Nashville Tennessee USA"},{"name":"Vanderbilt University Institute of Imaging Science Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baxter P.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Vanderbilt University  Nashville Tennessee USA"},{"name":"Vanderbilt University Institute of Imaging Science Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawniqua Williams","family":"Roberson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Vanderbilt University  Nashville Tennessee USA"},{"name":"Department of Neurology Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0334-539X","authenticated-orcid":false,"given":"Stefano","family":"Meletti","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Science University of Modena and Reggio Emilia  Modena Italy"},{"name":"Neurophysiology Unit and Epilepsy Center, Neuroscience Department Modena AOU  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6280-7526","authenticated-orcid":false,"given":"Anna E.","family":"Vaudano","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Science University of Modena and Reggio Emilia  Modena Italy"},{"name":"Neurophysiology Unit and Epilepsy Center, Neuroscience Department Modena AOU  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catie","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Vanderbilt University  Nashville Tennessee USA"},{"name":"Department of Electrical and Computer Engineering Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario J.","family":"Englot","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Vanderbilt University  Nashville Tennessee USA"},{"name":"Vanderbilt University Institute of Imaging Science Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Neurology Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Electrical and Computer Engineering Vanderbilt University  Nashville Tennessee USA"},{"name":"Department of Neurological Surgery Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria L.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Vanderbilt University  Nashville Tennessee USA"},{"name":"Vanderbilt University Institute of Imaging Science Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Neurology Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Neurological Surgery Vanderbilt University Medical Center  Nashville Tennessee 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