{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T10:19:40Z","timestamp":1787998780960,"version":"build-2784847793"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["F31NS132519"],"award-info":[{"award-number":["F31NS132519"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS110810"],"award-info":[{"award-number":["R01NS110810"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS110869"],"award-info":[{"award-number":["R01NS110869"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS137604"],"award-info":[{"award-number":["R01NS137604"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH127848"],"award-info":[{"award-number":["R01MH127848"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH136674"],"award-info":[{"award-number":["R01MH136674"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Heterozygous loss\u2010of\u2010function variants in the gene\n                    <jats:italic>SCN1A<\/jats:italic>\n                    , which encodes the voltage\u2010gated sodium channel (VGSC) pore\u2010forming (\u03b1) subunit Na\n                    <jats:sub>V<\/jats:sub>\n                    1.1, lead to a spectrum of neurological disease, including Dravet syndrome. Na\n                    <jats:sub>V<\/jats:sub>\n                    1.1 is prominently expressed at the proximal portion of the axon initial segment (AIS) of fast\u2010spiking \u03b3\u2010aminobutyric acidergic parvalbumin\u2010expressing inhibitory interneurons (PV+INs). In Dravet syndrome (\n                    <jats:italic>Scn1a<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>+\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    haploinsufficient) mice, action potential firing is impaired in PV+INs during postnatal development; however, in mature animals, PV+IN fast\u2010firing frequency has recovered. We used detailed immunohistochemistry and microscopy to probe the mechanism of this functional recovery, investigating potential upregulation of other brain\u2010expressed VGSC subunits at the PV+IN AIS. We found a specific upregulation of Na\n                    <jats:sub>V<\/jats:sub>\n                    1.6 immunofluorescence at the AIS of PV+INs in adult (but not developing)\n                    <jats:italic>Scn1a<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>+\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    mice compared to wild type, with no upregulation of other brain\u2010expressed subunits Na\n                    <jats:sub>V<\/jats:sub>\n                    1.2 or Na\n                    <jats:sub>V<\/jats:sub>\n                    1.3. These results demonstrate one mechanism through which epilepsy\u2010related gene variants reorganize the developing brain and enact endogenous changes that may be at least partially compensatory.\n                  <\/jats:p>","DOI":"10.1002\/epi.70336","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T14:33:06Z","timestamp":1780929186000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Compensatory rearrangement of parvalbumin interneuron voltage\u2010gated sodium channel subunits in a mouse model of Dravet syndrome"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8978-7185","authenticated-orcid":false,"given":"Ania K.","family":"Dabrowski","sequence":"first","affiliation":[{"name":"Division of Neurology, Department of Pediatrics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ala","family":"Somarowthu","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6744-4835","authenticated-orcid":false,"given":"Sophie R.","family":"Liebergall","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Perelman School of Medicine at University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6856-2988","authenticated-orcid":false,"given":"Damaris N.","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department of Physiology Perelman School of Medicine at University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7404-735X","authenticated-orcid":false,"given":"Ethan M.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Department of Neuroscience Perelman School of Medicine at University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Epilepsy NeuroGenetics Initiative Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Department of Neurology Perelman School of Medicine at University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00030.2024"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/320609"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.01.006"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12099"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1754"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2008.06.008"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0193\u201018.2018"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/19336950.2023.2281714"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583\u2010020\u201000418\u20104"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110580"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adf7084"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.5.2352"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592\u2010021\u201001105\u20107"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.4161\/chan.26023"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2021.04.003"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51205"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1101\u201006.2006"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.083089"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2359"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25676"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201001851\u20109"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.413"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12593"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51684"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1998.tb01413.x"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epi.70336","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/epi.70336","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/epi.70336","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T10:05:21Z","timestamp":1787997921000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/epi.70336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,8]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/epi.70336"],"URL":"https:\/\/doi.org\/10.1002\/epi.70336","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,8]]},"assertion":[{"value":"2026-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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