{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:05:18Z","timestamp":1792591518696,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100015050","name":"Sociedad Espa\u00f1ola de Epilepsia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Developmental and epileptic encephalopathies (DEEs) are characterized by drug\u2010resistant seizures and developmental slowing\/regression. We examined the efficacy and tolerability of fenfluramine (FFA) in pediatric and adult patients with Lennox\u2013Gastaut syndrome (LGS), Dravet syndrome (DS), and other DEEs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this multicenter, retrospective, real\u2010world study, FFA treatment was initiated \u226512\u2009months before database closure. Data from patients' charts at 3, 6 and 12\u2009months were recorded in the Spanish Epilepsy Society's DEEs registry. Effectiveness endpoints included seizure reductions of 100%, \u226575%, and \u226550% (responder), median percent seizure reduction, and seizure worsening. Safety endpoints included adverse event (AE) rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 166 patients (LGS,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200984; DS,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200942; other DEE,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940; mean age 16.6\u2009\u00b1\u200912.1\u2009years [111 pediatric, median 10.1\u2009years; 55 adult, median 26.5\u2009years]). Patients had a median of 3 prior failed anti\u2010seizure medications (ASMs). At 12\u2009months, the median FFA dose was 0.49\u2009mg\/kg\/day, with 77.1% treatment retention. There was a 68.8% median reduction in seizure frequency between baseline and 12\u2009months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), with significant reductions across all diagnostic groups (LGS,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001; DS,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001; other DEE,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.004). The 12\u2010month \u226550% responder rate was 61%, with no statistically significant differences according to age. At 12\u2009months, there were significant reductions in the mean number of concomitant ASMs (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.004) and the proportion of patients requiring rescue medication (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). Meaningful improvements in Clinical Global Impression scores for cognition (59.3% of patients), behavior (40.9%), sleep (24.3%), and caregiver (44.8%) domains were observed. At 12\u2009months, AEs were reported in 68.1% of patients (mostly mild\u2010to\u2010moderate) and AEs leading to discontinuation in 12%, with no significant differences according to age.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>FFA was effective, with predictable tolerability, in patients with different DEEs and seizure types, supporting its use as an effective treatment option in pediatric and adult patients with DEEs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70342","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:58:22Z","timestamp":1782212302000},"page":"4536-4550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effectiveness and tolerability of fenfluramine in pediatric and adult patients with developmental and epileptic encephalopathies: A multicenter, retrospective, real\u2010world clinical\u2010practice study"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2080-8042","authenticated-orcid":false,"given":"Vicente","family":"Villanueva","sequence":"first","affiliation":[{"name":"Hospital Universitario y Polit\u00e9cnico La Fe, Member of ERN Epicare  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0247-9187","authenticated-orcid":false,"given":"Elena","family":"Gonz\u00e1lez\u2010Alguacil","sequence":"additional","affiliation":[{"name":"Hospital Universitario Ni\u00f1o Jes\u00fas  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Smeyers","sequence":"additional","affiliation":[{"name":"Hospital Universitario y Polit\u00e9cnico La Fe, Member of ERN Epicare  Valencia 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