{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:59:55Z","timestamp":1790675995138,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Ketogenic dietary therapies can reduce seizure frequency in drug\u2010resistant epilepsy, but adherence to the classical ketogenic diet is often poor. Intermittent fasting supplemented with medium\u2010chain triglycerides (MCTs) may offer a more feasible and less restrictive alternative. We assessed whether 16:8 intermittent fasting with exogenous MCT supplementation improves seizure outcomes in adults with drug\u2010resistant epilepsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective, single\u2010center, two\u2010period crossover pilot trial included adults (\u226518\u2009years) with drug\u2010resistant epilepsy and at least three seizures per month during the initial 4\u2010week baseline period. Participants completed two, 12\u2010week intervention periods\u2014(1) 16:8 intermittent fasting plus MCT supplementation (IF\u2013MCT) and (2) 16:8 intermittent fasting alone (IF)\u2014separated by a 4\u2010week washout period. Participants were allocated 1:1 to the initial sequence using deterministic alternating allocation. The primary endpoint was seizure frequency during IF\u2013MCT compared with IF and standard therapy during the baseline period. The trial was registered with\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      (NCT06013761).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 36 enrolled participants, 22 completed both intervention periods with evaluable seizure diary data and were included in per\u2010protocol analyses. During IF\u2013MCT, two participants (9%) achieved sustained seizure freedom. In post hoc analyses, the proportion of participants achieving earlier \u226550% seizure reduction was numerically higher during IF\u2013MCT than during IF (Breslow:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.233), although not statistically significant. Concentrations of ketone bodies and octanoic and decanoic acids increased during IF\u2013MCT, without an apparent correlation with seizure reduction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>In this exploratory crossover pilot trial, intermittent fasting combined with MCT supplementation was associated with a numerical, although not statistically significant, reduction in seizure frequency compared with intermittent fasting alone in adults with drug\u2010resistant epilepsy. Although the study was not powered to detect definitive differences, the observed trend suggests a potential signal of efficacy. As one of the first studies to evaluate this combined dietary approach using a crossover design, the results support further investigation in larger, adequately powered multicenter efficacy trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70343","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:54:26Z","timestamp":1782478466000},"page":"4618-4630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intermittent fasting with medium\u2010chain triglycerides in drug\u2010resistant epilepsy: A pilot crossover trial"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7002-6551","authenticated-orcid":false,"given":"Wiebke","family":"Hahn","sequence":"first","affiliation":[{"name":"Department of Neurology, FB 20 Philipps University of Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1585-8938","authenticated-orcid":false,"given":"Emily","family":"Falk","sequence":"additional","affiliation":[{"name":"Department of Neurology, FB 20 Philipps University of Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayla","family":"Balzter","sequence":"additional","affiliation":[{"name":"Department of Neurology, FB 20 Philipps University of Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Foer","sequence":"additional","affiliation":[{"name":"Department of Neurology, FB 20 Philipps University of Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanin","family":"Maierhofer","sequence":"additional","affiliation":[{"name":"Department of Neurology, FB 20 Philipps University of Marburg  Marburg 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