{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:58:12Z","timestamp":1790675892395,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000095","name":"Savoy Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT\u2010159448(CG)"],"award-info":[{"award-number":["PJT\u2010159448(CG)"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT\u2010175056(BF)"],"award-info":[{"award-number":["PJT\u2010175056(BF)"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Accurate presurgical evaluation should assess not only the location but also the spatial extent of epileptic activity relative to the surgical cavity, a practical approximation of the epileptogenic zone. We evaluated how electromagnetic source imaging (EMSI) and hemodynamic responses to epileptic discharges relate to the surgical cavity and postoperative outcome, and whether multimodal concordance improves surgical prediction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive patients with drug\u2010resistant focal epilepsy who underwent electroencephalography\/magnetoencephalography (EEG\/MEG), and EEG\/functional magnetic resonance imaging (EEG\/fMRI) followed by surgery and \u22651\u2010year postoperative follow\u2010up were included. EMSI was performed using maximum entropy on the mean. The most significant fMRI cluster was extracted. All results were projected onto a common cortical surface. Spatial concordance with the surgical cavity was quantified using spatial overlap (area under the receiver operating characteristic curve [AUC]), distance localization error (DLE), and spatial dispersion (SD). Predictive performance was evaluated using a combined spatial criterion (AUC &gt;0.70 and DLE\u2009=\u20090\u2009mm).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010five patients were included. EEG\/MEG, EEG\/fMRI, and multimodal analyses were contributive in 23, 14, and 12 patients, respectively. In the EEG\/MEG group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923), patients with good outcome showed higher spatial overlap (mean\u2009\u00b1\u2009standard deviation, AUC: 0.70\u2009\u00b1\u20090.14 vs 0.56\u2009\u00b1\u20090.18;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04), shorter DLE (4.83\u2009\u00b1\u20096.80\u2009mm vs 17.98\u2009\u00b1\u200914.39\u2009mm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), and a trend toward lower SD (24.45\u2009\u00b1\u200917.07\u2009mm vs 34.21\u2009\u00b1\u200914.22\u2009mm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.08) than patients with poor outcome. EEG\/fMRI (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914) exhibited similar trends without statistical significance. In predicting surgical outcome, EMSI achieved a negative predictive value of 62% and an accuracy of 61%, whereas EEG\/fMRI reached 83% and 86%, respectively. When both modalities were considered (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912), all patients with concordant resected findings achieved a good outcome, whereas 8 of 10 patients with discordant results did not.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>EEG\/MEG and EEG\/fMRI showed complementary profiles. Resection of EEG\/MEG localizations were more frequently associated with good outcome, whereas unresected EEG\/fMRI responses predicted poor outcome. Concordant and resected multimodal findings were associated with good outcome, supporting a quantitative multimodal approach in presurgical evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70347","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:21:38Z","timestamp":1783606898000},"page":"4493-4506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Complementary predictive value of electromagnetic source imaging and hemodynamic responses in epilepsy surgery: A quantitative spatial analysis"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7232-6673","authenticated-orcid":false,"given":"Chifaou","family":"Abdallah","sequence":"first","affiliation":[{"name":"Montreal Neurological Institute and Hospital, McGill University  Montr\u00e9al, Qu\u00e9bec Canada"},{"name":"Multimodal Functional Imaging Lab, Biomedical 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FratelloM BoniniF Medina VillalonVS CaiZ LinaJM et\u00a0al.Assessing strengths and limitations of magnetoencephalography source imaging with intracerebral EEG. 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