{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:36:05Z","timestamp":1791606965962,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Ceribell Inc.'s point\u2010of\u2010care electroencephalographic (EEG) system and artificial intelligence\u2010based Automated Seizure Burden Estimator (ASBE; ClarityPro) have US Food and Drug Administration clearance for diagnosing electrographic status epilepticus (ESE). The AccuRASE study using ASBE version 6 (V6) showed high negative predictive value (NPV) but limited sensitivity and positive predictive value (PPV) at certain thresholds. Version 8 (V8) is the updated algorithm trained with additional EEG samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We tested V8 on the previously used rapid\u2010response EEG test dataset (not used to train V8). Sensitivity, specificity, PPV, and NPV were compared against blinded expert annotations. ESE, ESE and possible ESE (ESE\/pESE), electrographic seizures (ESz), and Esz with highly epileptiform patterns (Esz\/HEPs) at burden thresholds of &gt;1%, &gt;10%, &gt;20%, &gt;50%, and &gt;90% were analyzed. Additionally, we evaluated the built\u2010in ESE and ESE\/pESE alerts (\u226590% over 5\u2009min, \u226520% over 1\u2009h, or \u226510 continuous minutes of seizure).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>V8 showed 100% sensitivity at lower thresholds (&gt;10%\u201320%) for ESE (V6 .86), without a specificity loss (V8 .9 vs. V6 .85), and retained NPV (V8 1.0 vs. V6 .99). Sensitivity at 50% threshold was .86 for ESE (V6 .71), and specificity was .94 (V6 .91); PPV for ESE was 30% for ESE and 80% for ESE\/pESE. The specificity for ESE remained high for 90% burden (V8 .96, V6 .97) but the sensitivity dropped (.29 vs. V6 .43). Sensitivity was lower for ESz\/HEPs (.54\u2009\u2192\u2009.44 at &gt;10% threshold), although the algorithm is not designed to detect HEPs. Built\u2010in alert analysis showed significantly improved sensitivity for ESE (.57\u2009\u2192\u2009.86); specificity and NPV remained high (&gt;.94).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>ASBE V8 showed meaningful improvements in sensitivity, continued excellent NPV, and improved built\u2010in alert accuracy for ESE and ESE\/pESE. The best seizure burden threshold for ruling out ESE now is 20% (vs. 10% with V6) and that for ruling in ESE\/pESE with reasonable certainty is 50% (vs. 90% with V6).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/epi.70352","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:36:53Z","timestamp":1782398213000},"page":"4843-4856","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Accuracy of the rapid\u2010response electroencephalography's Automated Seizure Burden Estimator: A follow\u2010up validation study of version 8 (\n                    <scp>AccuRASE II<\/scp>\n                    )"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0857-7993","authenticated-orcid":false,"given":"Zubeda B.","family":"Sheikh","sequence":"first","affiliation":[{"name":"Department of Neurology Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Department of Neurology Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5666-5234","authenticated-orcid":false,"given":"Michael W. K.","family":"Fong","sequence":"additional","affiliation":[{"name":"Department of Neurology Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Westmead Comprehensive Epilepsy Centre University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4518-8827","authenticated-orcid":false,"given":"Monica B.","family":"Dhakar","sequence":"additional","affiliation":[{"name":"Department of Neurology Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0683-8846","authenticated-orcid":false,"given":"Wei","family":"Fang","sequence":"additional","affiliation":[{"name":"Health Sciences Center, University of New Mexico  Albuquerque New Mexico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5490-8776","authenticated-orcid":false,"given":"Neishay","family":"Ayub","sequence":"additional","affiliation":[{"name":"Department of Neurology Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6258-3913","authenticated-orcid":false,"given":"Janine","family":"Molino","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Warren Alpert Medical School at Brown University; Biostatistics, Epidemiology, Research Design, and Informatics Core Rhode Island Hospital  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7118-3690","authenticated-orcid":false,"given":"Hiba A.","family":"Haider","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Chicago Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5418-674X","authenticated-orcid":false,"given":"Brandon","family":"Foreman","sequence":"additional","affiliation":[{"name":"Department of Neurology &amp; Rehabilitation Medicine University of Cincinnati Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4659-6861","authenticated-orcid":false,"given":"Emily J.","family":"Gilmore","sequence":"additional","affiliation":[{"name":"Department of Neurology Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1332-6478","authenticated-orcid":false,"given":"Moshe","family":"Mizrahi","sequence":"additional","affiliation":[{"name":"Department of Neurology &amp; Rehabilitation Medicine University of Cincinnati Medical Center  Cincinnati Ohio USA"},{"name":"Department of Neurology State University of New York Downstate Health Sciences University at One Brooklyn Health System  Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5122-7211","authenticated-orcid":false,"given":"Ioannis","family":"Karakis","sequence":"additional","affiliation":[{"name":"Department of Neurology Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Department of Neurology University of Crete School of Medicine  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1384-9794","authenticated-orcid":false,"given":"Sarah","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of South Carolina  Charleston South Carolina 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